Search Clinical Trials
 
By Condition
 
By Location (USA)
 
By Location (Other)
 
By Sponsor
 
Resources
 
Privacy Policy
 
About Us
Disclaimer
Women's Estrogen for Stroke Trial (WEST) Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Women's Estrogen for Stroke Trial (WEST) conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Women's Estrogen for Stroke Trial (WEST) Clinical research trials and Women's Estrogen for Stroke Trial (WEST) medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Women's Estrogen for Stroke Trial (WEST). Women's Estrogen for Stroke Trial (WEST) Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Women's Estrogen for Stroke Trial (WEST) clinical trial. Subjects often receive the most expert healthcare possible for their Women's Estrogen for Stroke Trial (WEST) condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.

Home > "W" Clinical Trials Conditions > Women's Estrogen for Stroke Trial (WEST)

Women's Estrogen for Stroke Trial (WEST)



Women's Estrogen for Stroke Trial (WEST)

For Condition: Stroke
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: To determine if estrogen hormone replacement therapy reduces the risk of stroke or death in postmenopausal women who have already had stroke or a transient ischemic attack (TIA).
Details: The researchers enrolled 664 postmenopausal women with an average age of 71 years who had experienced an ischemic stroke or a TIA within the previous 90 days. Ischemic strokes and TIAs result from blockages in the vessels that supply blood to the brain. Participants were given a number of initial assessments, including the NIH Stroke Scale (NIHSS) of neurological impairment and the Barthel index of functional ability in activities of daily living. In addition to the usual best care for patients who have had a stroke, women in the trial received either oral estrogen (estradiol 17-beta at the standard replacement dose of 1 mg daily) or a matching placebo. Patients were studied for an average of 2.8 years. They stopped receiving the estrogen or placebo if they had a stroke. The researchers found that there was no significant difference in the incidence of stroke or death in the women who were randomly assigned to receive estrogen instead of placebo. However, they found that the incidence of death due to stroke was higher in the estrogen group and that the non-fatal strokes in that group were associated with slightly worse neurological and functional impairments at 1 month after stroke. The risk of stroke within the first 6 months after enrollment in the study was also higher among women in the estrogen group. There were no significant differences between treatment groups in the number of TIAs or non-fatal heart attacks. However, participants receiving estrogen were more likely to experience gynecologic complications, particularly vaginal bleeding.
Eligibility:
Study Type:  Interventional, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: /
Genders: 
Protocol Entry Criteria: 
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
RalphHorwitz,  Principal Investigator,  Yale University


Additional Information:
Study ID Numbers:  R01NS31251; 
Study Start Date: December 1993
Record last reviewed: November 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00026039

Other Stroke Studies:
1. A Phase II Pilot Study of the Safety, Tolerability and Pharmacokinetics of Cerebrilâ„¢ in Patients with Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy

2. Families In Recovery From Stroke Trial (F.I.R.S.T.)

3. Antiplatelet therapy to prevent stroke in African Americans

4. A BOTOX ® Study for Stroke Patients with Muscle Tightness in the Wrist, Fingers, and Elbow and with Some Breathing Problems

5. Effects of Exercise on patients with Hemiparetic Stroke

Related Studies:

Other Stroke Clinical Trials
Other Clinical Trials
Other Clinical Trials

Women's Estrogen for Stroke Trial (WEST)
Modify your Search

  Other Stroke Clinical Trials
  Other Clinical Trials
  Other Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103