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Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters Clinical research trials and Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters. Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters clinical trial. Test subjects typically receive the most expert healthcare available for their Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "W" Clinical Trials Conditions > Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters  Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
For Condition: Thromboembolism
Status: Recruiting
Sponsor(s): Cancer Research Campaign Clinical Trials Centre ,
Synopsis: RATIONALE: Warfarin may be effective in preventing the formation of blood clots in patients with central venous catheters. PURPOSE: Randomized clinical trial to study the effectiveness of warfarin in preventing blood clots in cancer patients who have central venous catheters.
Details: OBJECTIVES: - Determine the utility of warfarin in reducing thrombosis rates in cancer patients with central venous catheters. - Compare the thrombosis rates in patients treated with different warfarin dosing schedules. - Compare the adverse events and survival of patients receiving or not receiving this drug. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to sclerosant potential of cytotoxic regimen (low vs high), site of placement of catheter (peripheral vs central), and duration of drug administration (brief infusion (under 24 hours) vs prolonged infusion (24 hours and over)). Patients are randomized to 1 of 3 arms. - Arm I: Patients receive no warfarin. - Arm II: Patients receive oral warfarin daily beginning 3 days before placement of central venous catheter (CVC) and continuing until CVC is removed or thrombosis occurs. - Arm III: Patients receive oral warfarin as in arm II, with dose adjustment after CVC placement to achieve and maintain INR level. Patients are followed at 12 months. PROJECTED ACCRUAL: A total of 1,400 patients (400 in arm I, 700 in arm II, and 300 in arm III) will be accrued for this study within 2 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 16 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically or cytologically confirmed cancer - Planned placement of central venous catheter (CVC) for administration of chemotherapy - No use of CVC for additional purposes except for antibiotic therapy or blood products PATIENT CHARACTERISTICS: Age: - 16 and over Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - WBC at least 2,000/mm3 - Platelet count at least 100,000/mm3 - Hemoglobin at least 10 g/dL - No congenital bleeding disorders Hepatic: - Not specified Renal: - Not specified Other: - No contraindication to warfarin - No anatomic lesions that bleed (e.g., duodenal ulcers) - Not pregnant or nursing - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - See Disease Characteristics Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified Other - No prior enrollment on this study - No concurrent therapy that would interfere with study drug - No concurrent warfarin
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AnnieYoung, Study Chair, Queen Elizabeth Hospital at University of Birmingham
Royal Preston Hospital *Recruiting*
Preston, England, PR2 9HT
United Kingdom
Recruiting John Wardle 44-1772-710-089
Ipswich Hospital NHS Trust *Recruiting*
Ipswich, England, IP4 5PD
United Kingdom
Recruiting Joanne Todd 44-1473-712-233
Queen Elizabeth Hospital at University of Birmingham *Recruiting*
Birmingham, England, B15 2TT
United Kingdom
Recruiting Annie Young 44-121-414-3787
Bristol Haematology and Oncology Centre *Recruiting*
Bristol, England, BS2 8ED
United Kingdom
Recruiting Stephen Falk 44-117-928-2412
Northern Centre for Cancer Treatment at Newcastle General Hospital *Recruiting*
Newcastle upon Tyne, England, NE4 6BE
United Kingdom
Recruiting H.H. Lucraft 44-191-273-8811
Addenbrooke's NHS Trust *Recruiting*
Cambridge, England, CB2 2QQ
United Kingdom
Recruiting Robert Marcus 44-1223-217-071
New Cross Hospital *Recruiting*
Wolverhampton, England, WV10 0QP
United Kingdom
Recruiting Vicky McLelland 44-1902-307-999
Worcester Royal Infirmary *Recruiting*
Worcester, England, WR5 1JG
United Kingdom
Recruiting Sue Sharp 44-1905-763-333
Huddersfield Royal Infirmary *Recruiting*
Huddersfield, West Yorks, England, HD3 3EA
United Kingdom
Recruiting Claire Rimmer 44-1484-422-191
Sandwell & West Birminghan NHS Trust *Recruiting*
West Bromwich, England, B71 4HJ
United Kingdom
Recruiting David Spooner 44-121-553-1831, Ext. 3558
Ninewells Hospital and Medical School *Recruiting*
Dundee, Scotland, DD1 9SY
United Kingdom
Recruiting Elaine Rankin 44-1382-425-543
Good Hope Hospital Trust *Recruiting*
West Midlands, England, B75 7RR
United Kingdom
Recruiting John Glaholm 44-121-627-2443
Royal South Hants Hospital *Recruiting*
Southampton, England, SO14 0YG
United Kingdom
Recruiting Peter Simmonds 44-23-8063-4288
South Tees Hospitals NHS Trust *Recruiting*
Middlesbrough, Cleveland, England, TS4 3BW
United Kingdom
Recruiting Roberta Donaghy 44-1642-850-850
Charing Cross Hospital *Recruiting*
London, England, W6 8RF
United Kingdom
Recruiting Reggie Haynes 44-20-8846-1478
St. James's University Hospital *Recruiting*
Leeds, England, LS9 7TF
United Kingdom
Recruiting Tim Perren 44-113-206-4670
Royal Hampshire County Hospital *Recruiting*
Winchester, England, SO22 5DG
United Kingdom
Recruiting Virginia Hall 44-0962-63-535
Cheltenham General Hospital *Recruiting*
Cheltenham, England, GL53 7AN
United Kingdom
Recruiting Steve Shepherd 0845-4224-316
City Hospital - Birmingham *Recruiting*
Birmingham, England, B18 7QH
United Kingdom
Recruiting Daniel Rea 44-121-507-5241
Diana Princess of Wales Hospital *Recruiting*
Grimsby, England, DN33 2BA
United Kingdom
Recruiting Paul Mack 44-1472-874-111
Oldchurch Hospital *Recruiting*
Romford, England, RM7 OBE
United Kingdom
Recruiting Alison Brownell 44-0170-345-533
Royal Infirmary *Recruiting*
Glasgow, Scotland, G4 0SF
United Kingdom
Recruiting Mike Soukop 44-141-211-1160
Royal Lancaster Infirmary *Recruiting*
Lancaster, England, LA1 4RP
United Kingdom
Recruiting Malcolm McIllmurray Not Available
Mount Vernon Hospital *Recruiting*
Northwood, England, HA6 2RN
United Kingdom
Recruiting Sara Barker 44-1923-844-533
Royal Devon and Exeter Hospital *Recruiting*
Exeter, England, EX2 5DW
United Kingdom
Recruiting C. Rowland 01392-402105
Clatterbridge Centre for Oncology NHS Trust *Recruiting*
Merseyside, England, CH63 4JY
United Kingdom
Recruiting Ernest Marshall 44-151-334-1155
Birmingham Heartlands and Solihull NHS Trust -Teaching *Recruiting*
Birmingham, England, B9 5SS
United Kingdom
Recruiting David Ferry 44-121-424-2000
Singleton Hospital *Recruiting*
Swansea, Wales, SA 2 8QA
United Kingdom
Recruiting C. Askill 44-1792-205-666
Cumberland Infirmary *Recruiting*
Carlisle, England, CA2 7HY
United Kingdom
Recruiting Jonathan Nicoll 01 228 814688
Guy's and St. Thomas' Hospitals NHS Trust *Recruiting*
London, England, SE1 9RT
United Kingdom
Recruiting Peter Harper 44-20-7955-2933
Plymouth Hospitals NHS Trust *Recruiting*
Plymouth, , PL8 8DH
United Kingdom
Recruiting Francis Daniel 44-1752-775-861
Essex County Hospital *Recruiting*
Colchester, England, C03 3NB
United Kingdom
Recruiting Suzanne Meekings 44-1206-853-535
St. Luke's Cancer Center *Recruiting*
Guildford, England, GU2 5XX
United Kingdom
Recruiting Clare Topham 0483-571122 ext. 6812
Velindre Cancer Center at Velinde Hospital *Recruiting*
Cardiff, Wales, CF14 2TL
United Kingdom
Recruiting Timothy Maughan 029-20-316206
St. Georges Hospital *Recruiting*
Lincoln, England, LN1 1EJ
United Kingdom
Recruiting Brenda Peek 01522 512 512
Airedale General Hospital *Recruiting*
West Yorkshire, England, BD20 6TD
United Kingdom
Recruiting S. Crawford 01535-652511
St. George's Hospital *Recruiting*
London, England, SW17 0QT
United Kingdom
Recruiting Fiona Lofts 44-20-8725-0231
Princess Royal Hospital *Recruiting*
Hull, England, HU8 9HE
United Kingdom
Recruiting M.E. Holmes 44-148-267-6624
Cookridge Hospital at Leeds Teaching Hospital NHS Trust *Recruiting*
Leeds, England, LS16 6QB
United Kingdom
Recruiting Matthew Seymour 44-113-392-4307
Additional Information:
Study ID Numbers: CDR0000068909; CRC-WARP,EU-20049
Study Start Date:
Record last reviewed: September 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00024297
Other Thromboembolism Studies:
1. Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer
2. Epidemiology of Venous Thromboembolism
3. Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
4. Prevention of Recurrent Venous Thromboembolism (PREVENT)
5. Gemcitabine With or Without Dalteparin in Treating Patients With Unresectable or Metastatic Pancreatic Cancer
Related Studies:
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Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
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