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Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support Clinical research trials and Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support. Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support clinical trial. Test subjects oftentimes recieve the best healthcare possible for their Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "V" Clinical Trials Conditions > Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support  Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support
Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support
For Condition: Pneumonia
Status: Recruiting
Sponsor(s): AstraZeneca ,
Synopsis: The purpose of the study is to find out if high dose antibiotic (meropenem, MERREM® I.V.), along with another drug called an aminoglycoside (a different type of antibiotic) is effective in decreasing or reducing the rate of antibiotic resistant Pseudomonas aeruginosa, Acinetobacter (germs that can cause pneumonia), and the rate of resistance in other difficult to treat germs which may cause hospital-acquired pneumonia requiring mechanical ventilatory support. The study hopes to show that by increasing the amount of meropenem administered and increasing the duration of infusion (release of the drug into the bloodstream), levels of the drug will stay at target levels in the bloodstream and decrease the ability of difficult to treat germs to resist, or not be killed by, the treatment using this antibiotic (meropenem) or other antibiotics.
Details:
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Onset or exacerbation of pneumonia at least 72 hours after admission to an acute care facility or onset of pneumonia in a nursing home or rehabilitation facility with subsequent transfer to an acute care facility - Diagnosis of hospital-acquired pneumonia requiring mechanical ventilatory support - Patient or Patient’s legal guardian must sign written informed consent for study participation, pretreatment, and Day 7 bronchoscopy Exclusion Criteria: - Patients with hospital-acquired pneumonia caused by pathogens resistant to MERREM - Patients with allergies to cephalosporins, penicillins and carbapenems - Patients taking anticonvulsant therapy for a known seizure disorder - Patients with lung cancer - Patients with cystic fibrosis, acquired immune deficiency syndrome (AIDS), neutropenia, active tuberculosis, or patients taking immunosuppressive therapy in preparation for or following an organ transplant. - Patients who are pregnant or breast feeding - Patients who are unlikely to survive - Patients with certain infections in another area requiring treatment with additional antibiotics - Patients with other underlying conditions that would make it difficult to interpret response to study drug. - Patients who have been part of another clinical study 30 days before entry into this study. - Patients with hypotension (systolic BP < 85mmHg) or acidosis (arterial pH <7.25 or serum bicarbonate <15 mg/dl) despite attempts at fluid resuscitation - Patients with profound hypoxia
Total Enrollment: 500
Location and Contact Information:
Additional Information:
Study ID Numbers: 3591IL/0082;
Study Start Date: November 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00050401
Other Pneumonia Studies:
1. Venticute in Patients with Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment
2. Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support
3. Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation
4. Intravenous azithromycin plus intravenous ceftriaxone followed by oral azithromycin with intravenous levofloxacin followed by oral levofloxacin for the treatment of moderate to severely ill hospitalized patients with community acquired pneumonia.
5. Tigecycline versus Imipenem/Cilastatin for the Treatment of Subjects with Nosocomial Pneumonia
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Ventilator-associated pneumonia / Hospital-acquired pneumonia requiring mechanical ventilatory support
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