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Vaccine Therapy in Treating Patients With Kidney Cancer Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Vaccine Therapy in Treating Patients With Kidney Cancer conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Vaccine Therapy in Treating Patients With Kidney Cancer Clinical research trials and Vaccine Therapy in Treating Patients With Kidney Cancer healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Vaccine Therapy in Treating Patients With Kidney Cancer. Vaccine Therapy in Treating Patients With Kidney Cancer Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Vaccine Therapy in Treating Patients With Kidney Cancer clinical trial. Participants typically obtain the most effective healthcare available for their Vaccine Therapy in Treating Patients With Kidney Cancer condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "V" Clinical Trials Conditions > Vaccine Therapy in Treating Patients With Kidney Cancer  Vaccine Therapy in Treating Patients With Kidney Cancer
Vaccine Therapy in Treating Patients With Kidney Cancer
For Condition: stage 3 renal cell cancer,stage 4 renal cell cancer,recurrent renal cell cancer
Status: Recruiting
Sponsor(s): Hoag Memorial Hospital Presbyterian ,
Synopsis: RATIONALE: Vaccines made from a patient's white blood cells and tumor cells may make the body build an immune response to kill tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of vaccine therapy in treating patients who have recurrent or stage III or stage IV kidney cancer.
Details: OBJECTIVES: - Determine the safety of immunization with in vitro-treated autologous tumor cells and dendritic cells with sargramostim (GM-CSF) in patients with stage III or IV or recurrent renal cell cancer. - Determine the frequency of conversion of delayed tumor hypersensitivity tests in these patients treated with this regimen. - Determine the progression-free and overall survival of these patients treated with this regimen. - Determine the objective tumor response rate in patients who still have measurable disease at the time they are treated with this regimen. OUTLINE: Patients are stratified according to measurable disease at the time vaccine therapy is initiated (yes vs no). Patients undergo tumor cell harvest. Patients with multiple persistent sites of metastatic disease following harvest receive systemic therapy (biologic therapy and/or chemotherapy) during tumor cell line expansion. Over 2-4 months, the tumor cell line is expanded, treated with interferon gamma, and irradiated. Patients undergo leukapheresis to obtain peripheral blood mononuclear cells (PBMC). The PBMC are incubated over 7 days with sargramostim (GM-CSF) and interleukin-4 to produce dendritic cells (DC). The DC are incubated over 2-3 days with the irradiated tumor cells from the autologous tumor cell line for antigen loading of the DC. Patients undergo delayed tumor hypersensitivity testing 1 week prior to vaccination and again at week 4. Patients receive vaccine therapy comprising autologous treated tumor cells and DC suspended in GM-CSF subcutaneously weekly for 3 weeks. Vaccine therapy continues monthly for 5 months in the absence of disease progression or unacceptable toxicity. Patients are followed every 2 months for 1 year and then every 3 months for 4 years. PROJECTED ACCRUAL: A total of 80 patients (40 per stratum) will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 16 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed renal cell carcinoma - Stage III or IV disease involving invasions beyond Gerota's fascia, regional lymph node involvement, or distant metastases OR - Recurrent disease involving lymph node metastases or soft tissue nodules - Measurable disease by anatomic-based radiological tests (unless no evidence of disease as documented by prior surgery) - Planned resection of tumor to establish an autologous tumor cell line - No active CNS metastases such as brain metastases, spinal cord compression, or leptomeningeal disease - Prior brain metastases or spinal cord compression allowed provided there is radiographic evidence of lack of progression and no requirement for pharmacologic doses of corticosteroids PATIENT CHARACTERISTICS: Age: - 16 and over Performance status: - ECOG 0-2 Life expectancy: - At least 4 months Hematopoietic: - Hematocrit greater than 25% - Platelet count greater than 100,000/mm3 - No ongoing transfusion requirements - No active blood clotting or bleeding diathesis Hepatic: - Bilirubin no greater than 2.0 mg/dL - Albumin at least 3.0 g/dL - No significant hepatic dysfunction Renal: - Creatinine no greater than 2.0 mg/dL - No significant renal dysfunction Cardiovascular: - No underlying cardiac disease associated with New York Heart Association class III or IV heart function - No unstable angina related to atherosclerotic cardiovascular disease Other: - No other malignancy within the past 5 years except carcinoma in situ, basal cell or localized squamous cell skin cancer, or localized prostate cancer - No active infection - No other active medical condition that could be eminently life threatening - Not pregnant - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - Other prior putative vaccines allowed - Recovered from prior biologic therapy - No concurrent biologic therapy except epoetin alfa for patients with hematocrit less than 36% Chemotherapy: - At least 3 weeks since prior chemotherapy and recovered - No concurrent chemotherapy Endocrine therapy: - See Disease Characteristics - No concurrent corticosteroids Radiotherapy: - At least 3 weeks since prior radiotherapy (including whole-brain radiotherapy) and recovered - No concurrent radiotherapy Surgery: - See Disease Characteristics - Recovered from prior surgery Other: - Concurrent bisphosphonates allowed for patients with lytic bone metastases - No concurrent digoxin or other medications designed to improve cardiac output - No other concurrent anticancer therapy or investigational therapy
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RobertDillman, Study Chair, Hoag Memorial Hospital Presbyterian
Hoag Memorial Hospital Presbyterian *Recruiting*
Newport Beach, California, 92658
United States
Recruiting Robert Dillman 949-760-2091
Additional Information:
Study ID Numbers: CDR0000068493; HOAG-VACCINE-RN,NCI-V01-1647
Study Start Date:
Record last reviewed: March 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00014131
Other Stage 4 Renal Cell Cancer Studies:
1. PEG-Interferon alfa-2b in Treating Patients With Metastatic Kidney Cancer
2. Chemotherapy in Treating Patients With Metastatic Kidney Cancer
3. Interleukin-2, Vinblastine, and GM-CSF in Treating Patients With Metastatic Kidney Cancer
4. Erlotinib in Treating Patients With Locally Advanced or Metastatic Papillary Renal Cell Cancer
5. BAY 56-3722 in Treating Patients With Recurrent, Unresectable, or Metastatic Kidney Cancer
Related Studies:
Other stage 4 renal cell cancer Clinical Trials
Other California Clinical Trials
Other Newport Beach Clinical Trials
Vaccine Therapy in Treating Patients With Kidney Cancer
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