|
Tuberculosis Prophylaxis in the Homeless--A Controlled Trial Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Tuberculosis Prophylaxis in the Homeless--A Controlled Trial conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Tuberculosis Prophylaxis in the Homeless--A Controlled Trial Clinical research trials and Tuberculosis Prophylaxis in the Homeless--A Controlled Trial healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Tuberculosis Prophylaxis in the Homeless--A Controlled Trial. Tuberculosis Prophylaxis in the Homeless--A Controlled Trial Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Tuberculosis Prophylaxis in the Homeless--A Controlled Trial clinical trial. Subjects frequently obtain the most expert healthcare possible for their Tuberculosis Prophylaxis in the Homeless--A Controlled Trial condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "T" Clinical Trials Conditions > Tuberculosis Prophylaxis in the Homeless--A Controlled Trial  Tuberculosis Prophylaxis in the Homeless--A Controlled Trial
Tuberculosis Prophylaxis in the Homeless--A Controlled Trial
For Condition: Tuberculosis,Lung Diseases
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To conduct a three-arm, randomized controlled trial of methods to improve adherence to biweekly directly observed prophylaxis (DOPT) for tuberculosis in homeless adults in San Francisco.
Details: BACKGROUND: Tuberculosis was on the decline from the mid 1950s until the mid 1980s; however, the United States is now experiencing a resurgence of tuberculosis. In 1992, approximately 27,000 new cases were reported, an increase of about 20 percent from 1985 to 1992. Not only are tuberculosis cases on the increase, but a serious aspect of the problem is the recent occurence of outbreaks of multidrug resistant (MDR) tuberculosis, which poses an urgent public health problem and requires rapid intervention. Control programs involve two major components. First, and of highest priority, is to detect persons with active tuberculosis and treat them with effective antituberculosis drugs, which prevents death from tuberculosis and stops the transmission of infection to other persons. Treatment of active tuberculosis involves taking multiple antituberculosis drugs daily or several times weekly for at least six months. Failure to take the medications for the full treatment period may mean that the disease is not cured and may recur. If sufficient medications are not prescribed early and taken regularly, the tuberculosis organism can become resistant to the drugs, and the drug resistant tuberculosis then may be transmitted to other persons. Drug resistant disease is difficult and expensive to treat, and in some cases, cannot be treated with available medications. The second major goal of control efforts is the detection and treatment of persons who do not have active tuberculosis, but who have latent tuberculosis infection. These people may be at high risk of developing active tuberculosis. The only approved treatment modality for preventive therapy requires treatment daily or twice weekly for a minimum of six months, and many patients do not complete the full course of therapy. Public and patient programs are needed to increase the awareness of the problems associated with tuberculosis control. The study is part of the NHLBI initiative "Behavioral Interventions for Control of Tuberculosis" . The concept for the initiative originated from the National Institutes of Health Working Group on Health and Behavior. The Request for Applications was released in October, 1994. DESIGN NARRATIVE: Three approaches were compared for improving adherence to biweekly directly observed prophylaxis for tuberculosis in the homeless: $5 biweekly money incentive (MI) for adherence to DOPT, $5 value biweekly non-money incentive (NMI) for adherence to DOPT, and $5 biweekly money incentive supplemented by a peer community outreach worker (MI + PCOW). The outreach worker assisted subjects with completion of adherence to DOPT. Predictors of adherence to DOPT were examined, including sociodemographic, psychological and behavioral, and environmental factors.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AndrewMoss, , University of California
Additional Information:
Study ID Numbers: 4946;
Study Start Date: September 1995
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005737
Other Tuberculosis Studies:
1. Inhaled NO in Prevention of Chronic Lung Disease
2. Premature Birth and its Sequelae in Women
3. Prospective Evaluation of Airways Reactivity
4. Pulmonary Complications of HIV Infection Study (PACS)
5. Inhaled NO for the Prevention of Chronic Lung Disease
Related Studies:
Other Tuberculosis Clinical Trials
Other Clinical Trials
Other Clinical Trials
Tuberculosis Prophylaxis in the Homeless--A Controlled Trial
|
|
|
|
|
|
|
|
