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Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach Clinical research trials and Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach. Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach clinical trial. Participants frequently obtain the most expert healthcare available for their Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.

Home > "T" Clinical Trials Conditions > Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach

Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach



Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach

For Condition: Adenocarcinoma of the Esophagus,Gastric Cancer,Esophageal Cancer
Status: Completed
Sponsor(s): National Cancer Institute (NCI) , Southwest Oncology Group
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs such as triacetyluridine may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase II trial to study the effectiveness of triacetyluridine, fluorouracil, and leucovorin in treating patients who have unresectable , locally advanced, or metastatic cancer of the esophagus or stomach.
Details: OBJECTIVES: I. Assess the 6-month survival rate in patients with unresectable, locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction treated with triacetyluridine, fluorouracil, and leucovorin calcium. II. Evaluate the qualitative and quantitative toxic effects of this regimen in these patients. PROTOCOL OUTLINE: This is a multicenter study. Patients receive leucovorin calcium IV over 2 hours and fluorouracil IV over 30 minutes beginning 1 hour into leucovorin calcium infusion on days 1, 8, 15, 22, 29, and 36. Patients receive oral triacetyluridine every 8 hours on days 1-3, 8-10, 15-17, 22-24, 29-31, and 36-38 beginning 8 hours after completion of each fluorouracil infusion. Courses repeat every 8 weeks in the absence of disease progression or unacceptable toxicity. Patients are followed every 6 months for up to 3 years. PROJECTED ACCRUAL: A total of 53 patients will be accrued for this study.
Eligibility:
Study Type:
  Interventional, Educational/Counseling/Training
Minimum Age/Maximum Age: 18 Years/
Genders: 
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Histologically or cytologically proven unresectable, locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction - No known brain metastases Negative brain imaging required for neurologic signs and symptoms --Prior/Concurrent Therapy-- - Biologic therapy: No prior biologic therapy No concurrent biologic therapy - Chemotherapy: No prior chemotherapy for advanced or metastatic gastric cancer At least 6 months since prior chemotherapy as adjuvant or radiation sensitizer - Endocrine therapy: Not specified - Radiotherapy: At least 1 month since prior radiotherapy and recovered No concurrent radiotherapy - Surgery: At least 3 weeks since prior major surgical resection of intra-abdominal organs and recovered --Patient Characteristics-- - Age: 18 and over - Performance status: Zubrod 0-1 - Life expectancy: Not specified - Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count greater than 100,000/mm3 - Hepatic: Bilirubin no greater than upper limit of normal (ULN) SGOT or SGPT no greater than 1.5 times ULN (5 times ULN if liver tumor present) - Renal: Creatinine no greater than ULN - Other: Not pregnant or nursing Fertile patients must use effective contraception Must be able to swallow oral medication No AIDS syndrome or HIV-associated complex No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated stage I or II cancer in complete remission
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
JamesDoroshow,  Study Chair,  Southwest Oncology Group

MBCCOP - University of Illinois at Chicago
Chicago,  Illinois,  60612-7323
United States
 

Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock,  Arkansas,  72205
United States
 

Veterans Affairs Medical Center - Tucson
Tucson,  Arizona,  85723
United States
 

University of Arkansas for Medical Sciences
Little Rock,  Arkansas,  72205
United States
 

Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain,  Massachusetts,  02130
United States
 

CCOP - Santa Rosa Memorial Hospital
Santa Rosa,  California,  95403
United States
 

CCOP - Ann Arbor Regional
Ann Arbor,  Michigan,  48106
United States
 

Veterans Affairs Medical Center - Albuquerque
Albuquerque,  New Mexico,  87108-5138
United States
 

Barbara Ann Karmanos Cancer Institute
Detroit,  Michigan,  48201-1379
United States
 

CCOP - Northwest
Tacoma,  Washington,  98405-0986
United States
 

MBCCOP - LSU Health Sciences Center
New Orleans,  Louisiana,  70112
United States
 

University of Texas Health Science Center at San Antonio
San Antonio,  Texas,  78284-7811
United States
 

Loyola University Medical Center
Maywood,  Illinois,  60153
United States
 

Veterans Affairs Outpatient Clinic - Martinez
Martinez,  California,  94553
United States
 

UCSF Cancer Center and Cancer Research Institute
San Francisco,  California,  94143-0128
United States
 

MBCCOP - University of New Mexico HSC
Albuquerque,  New Mexico,  87131
United States
 

Medical University of South Carolina
Charleston,  South Carolina,  29425-0721
United States
 

CCOP - Wichita
Wichita,  Kansas,  67214-3882
United States
 

University of California Davis Medical Center
Sacramento,  California,  95817
United States
 

CCOP - Virginia Mason Research Center
Seattle,  Washington,  98101
United States
 

CCOP - Duluth
Duluth,  Minnesota,  55805
United States
 

Herbert Irving Comprehensive Cancer Center
New York City,  New York,  10032
United States
 

Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago,  Illinois,  60612
United States
 

David Grant Medical Center
Travis Air Force Base,  California,  94535
United States
 

Huntsman Cancer Institute
Salt Lake City,  Utah,  84112
United States
 

University of Rochester Medical Center
Rochester,  New York,  14642
United States
 

Veterans Affairs Medical Center - Charleston
Charleston,  South Carolina,  29401-5799
United States
 

University of Mississippi Medical Center
Jackson,  Mississippi,  39216-4505
United States
 

Madigan Army Medical Center
Tacoma,  Washington,  98431-5000
United States
 

Veterans Affairs Medical Center - Temple
Temple,  Texas,  76504
United States
 

Veterans Affairs Medical Center - Phoenix (Hayden)
Phoenix,  Arizona,  85012
United States
 

Cleveland Clinic Taussig Cancer Center
Cleveland,  Ohio,  44195
United States
 

Oregon Cancer Center
Portland,  Oregon,  97201-3098
United States
 

St. Louis University Health Sciences Center
St. Louis,  Missouri,  63110-0250
United States
 

Barrett Cancer Center, The University Hospital
Cincinnati,  Ohio,  45267-0502
United States
 

University of Texas - MD Anderson Cancer Center
Houston,  Texas,  77030-4009
United States
 

CCOP - Cancer Research for the Ozarks
Springfield,  Missouri,  65807
United States
 

Veterans Affairs Medical Center - New Orleans
New Orleans,  Louisiana,  70112
United States
 

CCOP - Upstate Carolina
Spartanburg,  South Carolina,  29303
United States
 

Veterans Affairs Medical Center - Wichita
Wichita,  Kansas,  67218
United States
 

CCOP - Dayton
Kettering,  Ohio,  45429
United States
 

Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio,  Texas,  78284
United States
 

Brooke Army Medical Center
Fort Sam Houston,  Texas,  78234
United States
 

CCOP - Central Illinois
Decatur,  Illinois,  62526
United States
 

CCOP - Toledo Community Hospital Oncology Program
Toledo,  Ohio,  43623-3456
United States
 

Veterans Affairs Medical Center - Dayton
Dayton,  Ohio,  45428
United States
 

Veterans Affairs Medical Center - Albany
Albany,  New York,  12208
United States
 

Veterans Affairs Medical Center - Oklahoma City
Oklahoma City,  Oklahoma,  73104
United States
 

St. Vincents Comprehensive Cancer Center
New York City,  New York,  10011
United States
 

CCOP - Columbus
Columbus,  Ohio,  43206
United States
 

USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles,  California,  90033-0804
United States
 

CCOP - Southeast Cancer Control Consortium
Winston Salem,  North Carolina,  27104-4241
United States
 

Tulane University School of Medicine
New Orleans,  Louisiana,  70112
United States
 

Veterans Affairs Medical Center - Detroit
Detroit,  Michigan,  48201-1932
United States
 

Veterans Affairs Medical Center - Kansas City
Kansas City,  Missouri,  64128
United States
 

Veterans Affairs Medical Center - Cincinnati
Cincinnati,  Ohio,  45220-2288
United States
 

CCOP - Bay Area Tumor Institute
Oakland,  California,  94609-3305
United States
 

Veterans Affairs Medical Center - Biloxi
Biloxi,  Mississippi,  39531-2410
United States
 

Oklahoma Medical Research Foundation
Oklahoma City,  Oklahoma,  73104
United States
 

University of Kansas Medical Center
Kansas City,  Kansas,  66160-7357
United States
 

Dwight David Eisenhower Army Medical Center
Fort Gordon,  Georgia,  30905-5650
United States
 

Veterans Affairs Medical Center - Ann Arbor
Ann Arbor,  Michigan,  48105
United States
 

CCOP - Columbia River Program
Portland,  Oregon,  97213
United States
 

Veterans Affairs Medical Center - Portland
Portland,  Oregon,  97207
United States
 

Arizona Cancer Center
Tucson,  Arizona,  85724
United States
 

CCOP - Montana Cancer Consortium
Billings,  Montana,  59101
United States
 

University of Michigan Comprehensive Cancer Center
Ann Arbor,  Michigan,  48109-0752
United States
 

Veterans Affairs Medical Center - Houston
Houston,  Texas,  77030
United States
 

Providence Hospital - Southfield
Southfield,  Michigan,  48075-9975
United States
 

Cancer Center and Beckman Research Institute, City of Hope
Duarte,  California,  91010-3000
United States
 

Chao Family Comprehensive Cancer Center
Orange,  California,  92868
United States
 

CCOP - Scott and White Hospital
Temple,  Texas,  76508
United States
 

CCOP - Greenville
Greenville,  South Carolina,  29615
United States
 

Veterans Affairs Medical Center - Salt Lake City
Salt Lake City,  Utah,  84148
United States
 

Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines,  Illinois,  60141
United States
 

Veterans Affairs Medical Center - Shreveport
Shreveport,  Louisiana,  71130
United States
 

University of Colorado Cancer Center
Denver,  Colorado,  80010
United States
 

CCOP - Kansas City
Kansas City,  Missouri,  64131
United States
 

Veterans Affairs Medical Center - West Los Angeles
Los Angeles,  California,  90073
United States
 

Veterans Affairs Medical Center - Denver
Denver,  Colorado,  80220
United States
 

Veterans Affairs Medical Center - Seattle
Seattle,  Washington,  98108
United States
 

CCOP - Atlanta Regional
Atlanta,  Georgia,  30342-1701
United States
 

Keesler Medical Center - Keesler AFB
Keesler AFB,  Mississippi,  39534-2576
United States
 

Veterans Affairs Medical Center - Lexington
Lexington,  Kentucky,  40511-1093
United States
 

Swedish Cancer Institute
Seattle,  Washington,  98104
United States
 

Louisiana State University Health Sciences Center - Shreveport
Shreveport,  Louisiana,  71130-3932
United States
 

Albert B. Chandler Medical Center, University of Kentucky
Lexington,  Kentucky,  40536-0084
United States
 

Boston Medical Center
Boston,  Massachusetts,  02118
United States
 

CCOP - Greater Phoenix
Phoenix,  Arizona,  85006-2726
United States
 

University of Texas Medical Branch
Galveston,  Texas,  77555-0209
United States
 

CCOP - Grand Rapids Clinical Oncology Program
Grand Rapids,  Michigan,  49503
United States
 

Henry Ford Hospital
Detroit,  Michigan,  48202
United States
 

Jonsson Comprehensive Cancer Center, UCLA
Los Angeles,  California,  90095-1781
United States
 

Cancer Research Center of Hawaii
Honolulu,  Hawaii,  96813
United States
 

Veterans Affairs Medical Center - Jackson
Jackson,  Mississippi,  39216
United States
 

CCOP - St. Louis-Cape Girardeau
St. Louis,  Missouri,  63141
United States
 

MBCCOP - Gulf Coast
Mobile,  Alabama,  36688
United States
 


Additional Information:
Study ID Numbers:
  CDR0000067477;  SWOG-S9915
Study Start Date: February 2001
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004233

Other Esophageal Cancer Studies:
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2. Irinotecan and Capecitabine in Treating Patients With Solid Tumors

3. Study of Decitabine in Preventing Tumor Growth

4. Oblimersen, Cisplatin, and Fluorouracil in Treating Patients With Advanced Esophageal, Gastroesophageal Junction, or Stomach Cancer

5. Monoclonal Antibody ABX-EGF in Treating Patients With Renal (Kidney), Prostate, Pancreatic, Non-Small Cell Lung, Colon or Rectal, Esophageal, or Gastroesophageal Junction Cancer

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Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach

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