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Treatment of Parkinson's Disease with Eliprodil



Treatment of Parkinson's Disease with Eliprodil

For Condition: Movement Disorders,Parkinson Disease
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia. Patients with the disease experience, rigid muscles, stooped posture, and a shuffling-type walk (gait). In this study researchers plan to evaluate the effectiveness of the drug eliprodil for the treatment of Parkinson's Disease. Eliprodil works by blocking special receptors (NMDA) that are associated with the symptoms of Parkinson's Disease.
Details: The objectives of this study are to evaluate the acute effects of the NR2B subtype-selective NMDA antagonist eliprodil on levodopa-associated motor response complications in patients with advanced Parkinson's Disease (PD).
Eligibility:
Study Type:
  Interventional, Treatment, Safety/Efficacy
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: All patients will carry a diagnosis of idiopathic Parkinson's Disease based on the presence of a characteristic clinical history and neurologic findings. Most will have relatively advanced disease with associated motor response complications. Males and females between the ages of 18-75. No presence or history of any medical condition that can reasonably be expected to subject the patient to unwarranted risk. No patients with baseline QTc prolongation (greater than 440 msec). No pregnant women nor those not practicing effective means of birth control.
Total Enrollment: 20

Location and Contact Information:

National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:
  990078;  99-N-0078
Study Start Date: March 26, 1999
Record last reviewed: January 4, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001929

Other Movement Disorders Studies:
1. To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)

2. Continuously Infused Intracerebral (IC) Recombinant-Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (r-metHuGDNF) for the Treatment of Idiopathic Parkinson's Disease

3. Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease

4. Treatment of Depression in Parkinson’s Disease Trial

5. Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

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Other Movement Disorders Clinical Trials
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Other Bethesda Clinical Trials

Treatment of Parkinson's Disease with Eliprodil

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