|
Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation Clinical research trials and Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation. Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation clinical trial. Subjects typically recieve the finest healthcare available for their Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "T" Clinical Trials Conditions > Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation  Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation
Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation
For Condition: Movement Disorder,Myoclonus,Nervous System Disease
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Myoclonus is a condition related to epilepsy of involuntary twitching or jerking of the limbs. The purpose of this study is to determine if stimulation of the brain with magnetic pulses can decrease myoclonus. Researchers believe that this may be possible because in studies on normal volunteers, magnetic stimulation made areas of the brain difficult to activate for several minutes. In addition, early studies on patients with myoclonus have shown magnetic stimulation to be effective at decreasing involuntary movements. Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. It is very useful when studying the areas of the brain and spinal cord related to motor activity (motor cortex and corticospinal tract). Repetitive transcranial magnetic stimulation (rTMS) involves the placement of coil of wire (electromagnet) on the patient's scalp and rapidly turning on and off the electrical current. The changing magnetic field produces weak electrical currents in the brain near the coil. This permits non-invasive, relatively localized stimulation of the surface of the brain (cerebral cortex). The effect of magnetic stimulation varies, depending upon the location, intensity and frequency of the magnetic pulses. Researchers plan to use rTMS for 10 days on patients participating in the study. The 10 day period will be broken into 5 days of active repetitive magnetic stimulation and 5 days of placebo "ineffective" stimulation. At the end of the 10 day period, if the results show that rTMS was beneficial, patients may undergo an additional 5 days of active rTMS.
Details: Repetitive transcranial magnetic stimulation (rTMS) at frequencies in the single Hz range causes a decrease in the excitability of the primary motor cortex and there is preliminary evidence that it can suppress abnormal excess cortical activity. We plan to test 1 Hz rTMS as treatment for cortical myoclonus.
Eligibility:
Study Type: Interventional, Treatment, Safety
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Age 5 to 90 with severe cortical myoclonus. No intracranial metal hardware (excluding dental fillings), pacemakers, indwelling medication pumps, cochlear implants, intracardiac lines, significant intracranial masses or increased intracranial pressure. Subject must not be pregnant.
Total Enrollment: 10
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 970053; 97-N-0053
Study Start Date: January 8, 1997
Record last reviewed: January 16, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001663
Other Movement Disorder Studies:
1. Phenotype/Genotype Correlations in Movement Disorders
2. Magnetic Resonance Imaging Studies of Motor and Thought Processes
3. Human Movement Database
4. Study of Brain Control of Movement
5. Botulinum Toxin for the Treatment of Involuntary Movement Disorders
Related Studies:
Other Movement Disorder Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Treatment of Cortical Myoclonus with Repetitive Transcranial Magnetic Stimulation
|
|
|
|
|
|
|
|
