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Treatment of Acute HIV Infection to Preserve Immune Function



Treatment of Acute HIV Infection to Preserve Immune Function

For Condition: HIV Infections
Status: Completed
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: While most people with HIV experience significant destruction of their immune systems, some people appear to have preserved immune function and can control the virus without drugs. Early treatment with anti-HIV drugs may help preserve the immune system, allowing it to control the virus once the drugs are stopped. This study will evaluate the immune system response of HIV infected people who are treated with anti-HIV drugs soon after being infected.
Details: Studies have identified a potent CD4 T helper (Th) cell response in some infected people, and have shown a correlation between virus-specific Th cells and low levels of viremia. Early institution of potent antiviral therapy in the earliest stages of acute HIV infection have led to strong Th cell responses, analogous to those seen in people who are able to control viremia in the absence of antiviral therapy. This may be because potent antiviral therapy is able to protect virus-specific Th cells as they become activated, and thus these cells are not lost in the earliest stages of infection. This study will characterize the immune response of patients with acute HIV infection who receive antiretroviral therapy and will determine the effects of interruption of therapy in those people who have immune responses to HIV that are similar to patients with long-term non-progressing infection. Participants in this study will be followed through June 2004. Study visits vary from only once to every month and are scheduled at the discretion of the study officials. Study visits include an interview and blood tests.
Eligibility:
Study Type:  Observational, Natural History, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Acute HIV infection
Total Enrollment: 500

Location and Contact Information:

Overall Study Official:
BruceWalker,  Principal Investigator,  Massachusetts General Hospital

Massachusetts General Hospital
Boston,  Massachusetts,  02116
United States
 


Additional Information:
Study ID Numbers:  1R01AI44656-01;  5R01AI044656-04
Study Start Date: July 1999
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00055094

Other Hiv Infections Studies:
1. A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV Infection

2. The Biology of HIV Transmission

3. The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood

4. A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and Leukopenia

5. A Study of Dideoxycytidine in HIV-Infected Patients

Related Studies:

Other HIV Infections Clinical Trials
Other Massachusetts Clinical Trials
Other Boston Clinical Trials

Treatment of Acute HIV Infection to Preserve Immune Function
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