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Treatment for Post-Stroke Depression



Treatment for Post-Stroke Depression

For Condition: Depression,Stroke
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: The purpose of this study is to evaluate a program of education, medicine, and monitoring for the treatment of depression after a stroke.
Details: This trial will compare outcomes in depressed patients receiving the Activate-Initiate-Monitor (AIM) intervention vs. those receiving usual care, and will also compare outcomes in depressed and non-depressed stroke survivors. Patients are screened for depression 1 to 2 months post-stroke. Patients with depression are then randomized to the AIM intervention or control group. Patients without depression are also enrolled at the same time and are matched by hospital site to the depressed patients. The AIM intervention is a 3-part program consisting of activating or educating the patient and his/her family about post-stroke depression, instituting treatment for depression, and monitoring antidepressant treatments for side effects, efficacy, and compliance. Control patients are evaluated and treated with usual care by their physicians. Patients without depression do not receive the intervention but complete the same assessments on the same schedule as the patients with depression.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Single Blind
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: - No severe language or cognitive deficits, - life expectancy of at least 9 months, and - willingness to participate.
Total Enrollment: 780

Location and Contact Information:

Overall Study Official:
LindaWilliams,  Principal Investigator,  Roudebush VA Medical Center Health Services Research and Development 11H

Roudebush VA Medical Center, Health Services Research and Development 11H, 1481 W. 10th Street *Recruiting*
Indianapolis,  Indiana,  46202
United States
Recruiting Laurie  Plue 317-554-0000

Indiana University Hospital, 550 N. University Blvd. *Recruiting*
Indianapolis,  Indiana,  46202
United States
Recruiting Laurie  Plue 317-554-0000

Wishard Memorial Hospital, 1001 W. 10th Street *Recruiting*
Indianapolis,  Indiana,  46202
United States
Recruiting Laurie  Plue 317-554-0000

Methodist Hospital of Indiana, 1601 N. Capitol *Recruiting*
Indianapolis,  Indiana,  46202
United States
Recruiting Laurie  Plue 317-554-0000


Additional Information:
Study ID Numbers:
  R01NS39571; 
Study Start Date: 
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00029172

Other Stroke Studies:
1. Treatments for Depression: Drug vs. Psychotherapy

2. Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation

3. Sertraline for Alcohol Dependence and Depression

4. Treatment of Depression in Youth with Bipolar Disorders

5. Preventing Post-Stroke Depression

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