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Home > "T" Clinical Trials Conditions > Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients  Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients
Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients
For Condition: Hypertension,Depression
Status: Not yet recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service , SmithKline Beecham
Synopsis: This study aims to determine if treatment with an SSRI antidepressant medication, paroxetine, is associated with cellular calcium response to serotonin, platelet serotonin receptors, and improvement in mood in depressed patients with or without hypertension. It is hypothesized that platelets of hypertensive patients with depressive symptomatology with be hyper-responsive to serotonin. Additionally, treatment with an SSRI antidepressant is expected to produce a down-regulation of the serotonin receptor with an associated reduction in platelet cytosolic calcium response as well as improved mood.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Parallel Assignment, Pharmacodynamics Study
Minimum Age/Maximum Age: 25 Years/65 Years
Genders: Male
Protocol Entry Criteria: Subjects for all study groups will be male and between the ages of 25 and 65 Hypertension & Depression Group: Hypertension controlled with an ACE-inhibitor anti-hypertensive; no co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; depression as diagnosed by structured interview and HDRS score of 18; no active participation in another clinical trial; no current suicidal/ homicidal ideation Hypertension Group: Hypertension controlled with an ACE-inhibitor anti-hypertensive; no co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; no active participation in another clinical trial; no current suicidal/ homicidal ideation Depression Group: No co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; depression as diagnosed by structured interview and HDRS score of 18; no active participation in another clinical trial; no current suicidal/ homicidal ideation
Total Enrollment:
Location and Contact Information:
Edward Hines Jr. Hospital
Hines, Illinois, 60141
United States
Lukasz Konopka 708-343-7200
Additional Information:
Study ID Numbers: MHBS-023-00S;
Study Start Date: March 2001
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018759
Other Hypertension Studies:
1. Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
2. Sertraline and Cognitive Therapy in Depressed Alcoholics
3. Depression In Juvenile Diabetics
4. Transcranial magnetic stimulation in depression
5. Dextroamphetamine-Amphetamine Compared With Methylphenidate in Treating Children With Depression and Problems With Memory, Attention, and Thinking Caused By Cancer Treatment
Related Studies:
Other Hypertension Clinical Trials
Other Illinois Clinical Trials
Other Hines Clinical Trials
Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients
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