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To study the use of Humanized CD25 in preventing the relapse of Psoriasis Vulgaris



To study the use of Humanized CD25 in preventing the relapse of Psoriasis Vulgaris

For Condition: Psoriasis
Status: Recruiting
Sponsor(s): Protein Design Labs ,
Synopsis: This study is designed to study disease relapse after NBUVB and how the administration of Daclizumab/placebo alters disease relapse.
Details: The first part of the study involves NB-UVB light treatment, a well-established treatment to treat psoriasis. In the second part, we are testing a drug known as Humanized CD25 Monoclonal Antibody (anti-TAC) or placebo to prevent disease relapse. Anti-TAC is an injectable medicine that is also designed to treat psoriasis by blocking a part of the immune system that we believe contributes to the disease.
Eligibility:
Study Type:  Interventional, Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: - extensive active psoriasis vulgaris, body surface area more than 10% if accompanied by psoriatic arthritis, - negative hepatitis and HIV, - no treatment with systemic drugs for 1 month prior to the start of a study - no treatment with topical medications for 2 weeks prior to the start of a study,
Total Enrollment: 30

Location and Contact Information:

Rockefeller University *Recruiting*
New York City,  New York,  10021
United States
Recruiting Pat  Gilleaudeau 212-327-8333


Additional Information:
Study ID Numbers:  JKR-0337; 
Study Start Date: October 1997
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00050661

Other Psoriasis Studies:
1. Etanercept (Enbrel®) in Psoriasis - Pediatrics

2. Micellar Paclitaxel to Treat Severe Psoriasis

3. A Pilot Study of Topical Antiflammin-2 for Psoriasis

4. A Controlled Trial of Intermittent Fludarabine for Psoriatic Arthritis

5. Randomized Double-Blind Placebo-Controlled Trial Using Recombinant Human Interleukin-10 for Moderate-to-Severe Psoriasis

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