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To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical research trials and To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements). To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) clinical trial. Subjects typically recieve the finest healthcare available for their To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
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Home > "T" Clinical Trials Conditions > To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)  To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
For Condition: Parkinson Disease,Dyskinesias,Movement Disorders
Status: No longer recruiting
Sponsor(s): IVAX Research ,
Synopsis: The purpose of this research study is to test the safety and effectiveness of the study drug, Talampanel, when used to treat patients with involuntary movements known as dyskinesias, as a result of treatment to Parkinson’s disease. It is not clear why people with Parkinson’s disease develop involuntary movements (dyskinesias) but studies show that blocking receptors in the brain for a chemical called glutamate decreases these movements. Talampanel is a drug which blocks these receptors.
Details:
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 40 Years/85 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Troublesome on-period dyskinesias as defined by a Unified Parkinson's Disease Rating Scale (UPDRS) dyskinesia sub-score >25% of Duration of dyskinesia during waking hours and 33 must have moderate disability - Lang-Fahn dyskinesia rating score more than 2 for at least two of the 5 tasks - Must have Dyskinesia on average 25% of waking hours/day based on Patient Diaries - Have been diagnosed with Parkinson's disease > 5 years at Screening Exclusion Criteria: - Previous surgical therapies for PD - Isolated or predominantly diphasic dyskinesias - Moderate Dementia - On disallowed concomitant medications including CYP3A4 inhibitors and inducers, amantadine, etc.
Total Enrollment: 33
Location and Contact Information:
Toronto Western Hospital, University Health Network
Toronto, Ontario, M5T 2S8
Canada
Mount Sinai School of Medicine
New York City, New York, 10029
United States
Emory University School of Medicine
Atlanta, Georgia, 30329
United States
Cleveland Clinic Florida
Weston, Florida, 33331
United States
Beth Israel Medical Center
New York City, New York, 10003
United States
Center for Movement Disorder
Markham, Ontario, L6B 1A1
Canada
Parkinson's Disease Movement Disorder Center of Boca Raton
Boca Raton, Florida, 33486
United States
Additional Information:
Study ID Numbers: IXL-202-18-189;
Study Start Date:
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00036296
Other Movement Disorders Studies:
1. Phase II Double Blind Controlled Trial of Nigral Grafting in Patients With Parkinson's Disease
2. How the loss of Dopamine and Dopamine-Restoring Medicines Affect Movement Performance
3. Chinese Exercise Modalities in Parkinson's Disease
4. GM1 Ganglioside Effects on Parkinson’s Disease
5. A study comparing the efficacy, safety, and tolerability of an investigational drug versus placebo or Ropinirole in patients with early Parkinson's Disease
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To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
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