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This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. Clinical research trials and This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.. This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. clinical trial. Participants typically obtain the most effective healthcare available for their This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC. condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "T" Clinical Trials Conditions > This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.  This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.
This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.
For Condition: Carcinoma, Non-Small-Cell Lung
Status: Recruiting
Sponsor(s): AstraZeneca ,
Synopsis: The purpose of this study is to compare the efficacy of ZD6474 and ZD1839 in patients with NSCLC after Failure of Prior Platinum-based Chemotherapy.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Uncontrolled, Crossover Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Prior histologic or cytologic confirmation of advanced (IIIB/IV) NSCLC - Failure of first-line platinum-based chemotherapy (the prior regimen must have failed the subject because of toxicity or progression of tumor) - WHO performance status of 0 or 1 - Life expectancy of 12 weeks or longer - Measurable disease (at least 1 target lesion) according to RECIST Exclusion Criteria: - Mixed small cell and non-small cell histology - Brain metastases or spinal cord compression, unless treated at least 4 weeks before entry and stable without steroid treatment for 1 week - Any unresolved chronic toxicity greater than CTC grade 2 from previous anticancer therapy - Prior treatment with agents that inhibit EGFR or VEGF signalling - Superior vena cava (SVC) syndrome - Significant cardiac event (including symptomatic heart failure or angina) within 3 months of entry or presence of any cardiac disease that in the opinion of the Investigator increases the risk of ventricular arrhythmia - History of clinically significant arrhythmia (multifocal PVCs, bigeminy, trigeminy,ventricular tachycardia, bradycardia) that is symptomatic or requires treatment (CTC grade 3) or a symptomatic sustained ventricular tachycardia - Chronic atrial fibrillation - Previous history of QTc prolongation while taking other medication Congenital long QT syndrome - Hypertension not controlled by medical therapy (systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 100 mmHg)
Total Enrollment: 160
Location and Contact Information:
Research Site *Recruiting*
Cardiff, ,
United Kingdom
Recruiting
Research Site *Recruiting*
Madison, Wisconsin,
United States
Recruiting
Research Site *Recruiting*
Wilrijk, ,
Belgium
Recruiting
Research Site *Recruiting*
Bloemfontein, ,
South Africa
Recruiting
Research Site *Recruiting*
Northwood, ,
United Kingdom
Recruiting
Research Site *Recruiting*
Bismark, North Dakota,
United States
Recruiting
Research Site *Recruiting*
Manchester, ,
United Kingdom
Recruiting
Research Site *Recruiting*
Panorama, ,
South Africa
Recruiting
Research Site *Recruiting*
Leeds, ,
United Kingdom
Recruiting
Research Site *Recruiting*
BRUXELLES, ,
Belgium
Recruiting
Research Site *Recruiting*
Shreveport, Louisiana,
United States
Recruiting
Research Site *Recruiting*
Brussel, ,
Belgium
Recruiting
Research Site *Recruiting*
Pretoria, ,
South Africa
Recruiting
Research Site *Recruiting*
Port Elizabeth, ,
South Africa
Recruiting
Research Site *Recruiting*
Indianapolis, Indiana,
United States
Recruiting
Research Site *Recruiting*
Saxonwold, ,
South Africa
Recruiting
Research Site *Recruiting*
Durban, ,
South Africa
Recruiting
Research Site *Recruiting*
St. Louis, Missouri,
United States
Recruiting
Research Site *Recruiting*
Groenkloof Pretoria, ,
South Africa
Recruiting
Research Site *Recruiting*
Palm Springs, California,
United States
Recruiting
Research Site *Recruiting*
San Diego, California,
United States
Recruiting
Research Site *Recruiting*
Edegem, ,
Belgium
Recruiting
Research Site *Recruiting*
New York City, New York,
United States
Recruiting
Research Site *Recruiting*
Greenville, North Carolina,
United States
Recruiting
Research Site *Recruiting*
Los Angeles, California,
United States
Recruiting
Research Site *Recruiting*
Edinburgh, ,
United Kingdom
Recruiting
Research Site *Recruiting*
LIEGE, ,
Belgium
Recruiting
Research Site *Recruiting*
Martinez, ,
Argentina
Recruiting
Research Site *Recruiting*
Coeur D Alene, Idaho,
United States
Recruiting
Research Site *Recruiting*
PARKTOWN, ,
South Africa
Recruiting
Research Site *Recruiting*
Buenos Aires, ,
Argentina
Recruiting
Research Site *Recruiting*
Boca Raton, Florida,
United States
Recruiting
Research Site *Recruiting*
Ramo Mejia, ,
Argentina
Recruiting
Additional Information:
Study ID Numbers: 6474IL/0003;
Study Start Date:
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00059722
Other Carcinoma, Non-Small-Cell Lung Studies:
1. ZD6474 Alone or in Combination with Paclitaxel and Carboplatin in Subjects with Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
2. A study with Gemzar, Cisplatin, and LY293111 in non-small cell lung cancer
3. Phase 1-2a Dose-Ranging Study of TLK286 in Combination with Docetaxel in Platinum-Resistant Non-Small Cell Lung Cancer
4. Study of 111In-DAC as an Medical Imaging Agent for Lung Cancer and Brain Cancer Consistent with Metastatic Lung Cancer
5. Phase 2 Study of TLK286 Administered Weekly in Advanced Non-Small Cell Lung Cancer
Related Studies:
Other Carcinoma, Non-Small-Cell Lung Clinical Trials
Other New York Clinical Trials
Other New York City Clinical Trials
This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.
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