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The Treatment and Natural History of Acromegaly



The Treatment and Natural History of Acromegaly

For Condition: Acromegaly,Pituitary Neoplasm
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: This study is directed toward acromegaly and treatment of patients with acromegaly. Acromegaly is a condition due to high levels of growth hormone in the blood. Growth hormone is responsible for the regulation of the metabolism of sugar, fat, and protein. When growth hormone levels are elevated patients may experience symptoms such as fatigue, sweating, joint pain, enlargement of the hands and feet, growth of soft tissues, and changes in the bones of the face and skull. Most patient suffering from acromegaly have a tumor of the pituitary gland known as an adenoma. It can be treated surgically or destroyed by radiation. Occasionally drugs are used to treat acromegaly. Researchers have followed groups of patients with acromegaly for 25 years. The study will allow researchers to continue monitoring these patients and recruit new patients into the study. The patients will provide researchers with blood samples and pituitary gland tumor samples (when available through clinical care). These samples will be saved to provide future information about the disease. The study will provide researchers with information needed to better understand the causes and treatment of acromegaly.
Details: The purpose of this study is to investigate the treatment and natural history of acromegaly. We have a longstanding interest in acromegaly treatment, and a cohort that has been followed for over 25 years in many cases. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to acromegaly.
Eligibility:
Study Type:  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION/EXCLUSION CRITERIA Patients will be enrolled who are 18 years of age or over who are referred for care. There are no exclusions.
Total Enrollment: 9999

Location and Contact Information:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) *Recruiting*
Bethesda,  Maryland,  20892
United States
Recruiting Patient  and Public Liaison Office 1-800-411-1222


Additional Information:
Study ID Numbers:  850082;  85-DK-0082
Study Start Date: April 15, 1985
Record last reviewed: March 16, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001981

Other Pituitary Neoplasm Studies:
1. A Study to Compare the Efficacy and Safety of Pegvisomant to that of Sandostatin LAR in Patients with Acromegaly

2. The Treatment and Natural History of Acromegaly

3. Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly

4. Measurement of Outcome of Surgical Treatment in Patients With Acromegaly

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