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The Effects of Sex Hormones on Cognition and Mood in Older Adults



The Effects of Sex Hormones on Cognition and Mood in Older Adults

For Condition: Cognition Disorders,Mood Disorders
Status: Terminated
Sponsor(s): National Institute on Aging (NIA) ,
Synopsis: This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.
Details: Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).
Eligibility:
Study Type:  Interventional, Treatment, Double-Blind, Placebo Control, Crossover Assignment
Minimum Age/Maximum Age: 65 Years/90 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Women and men aged 65-90 who have not received hormone replacement for the last three months. Exclusion Criteria: - Previous head injury with loss of consciousness for more than one hour. - Men with a history of prostate cancer. - Men on testosterone replacement within the past three months. - Women with a history of breast or uterine cancer. - Women on estrogen replacement within the past three months.
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
Dr.Maki,  Principal Investigator,  National Institute on Aging, Gerontology Research Center

Gerontology Research Center
Baltimore,  Maryland,  21224
United States
 


Additional Information:
Study ID Numbers:  IA0016; 
Study Start Date: 
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000175

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3. The Effects of Sex Hormones on Cognition and Mood in Older Adults

4. Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

5. Family Study of Affective and Anxiety Spectrum Disorders

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