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The Effects of r-metHuIFN-gamma on the Lungs of Patients with AIDS



The Effects of r-metHuIFN-gamma on the Lungs of Patients with AIDS

For Condition: HIV Infections
Status: Completed
Sponsor(s): Amgen ,
Synopsis: To determine safety and tolerance of administering aerosolized recombinant interferon gamma (IFN-gamma) for 4 weeks in patients with AIDS. To examine activation of alveolar macrophages by aerosolized IFN-gamma administration. To determine if subcutaneous (SC) injection of IFN-gamma can activate alveolar macrophages in AIDS patients.
Details:
Eligibility:
Study Type:  Interventional, Treatment, Safety Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - Diagnosis of AIDS with one or more opportunistic infections. - Kaposi's sarcoma with prior history of opportunistic infection. - Stable dose of zidovudine (AZT) therapy. - Preserved pulmonary, renal and hepatic function. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Presence of active infection. - Active opportunistic infections. - Cardiac disease. - Central nervous system disorders. - History of seizures. - Irreversible airway disease. Patients with the following are excluded: - Co-existing conditions and symptoms listed in Patient Exclusion Co-existing Conditions. Prior Medication: Excluded within 4 weeks of study entry: - Immunosuppressive therapy. - Cytotoxic therapy. - Excluded: - Interferon gamma therapy.
Total Enrollment: 12

Location and Contact Information:

New York Hosp - Cornell Med Ctr
New York City,  New York,  10021
United States
 


Additional Information:
Study ID Numbers:  062A;  IFNG-8901
Study Start Date: 
Record last reviewed: November 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002433

Other Hiv Infections Studies:
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2. A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis carinii Pneumonia in Patients with the Acquired Immunodeficiency Syndrome

3. A Study of Delavirdine Used Together with Other Anti-HIV Drugs in HIV-Infected Patients

4. Helping HIV Infected Patients in South Africa Adhere to Drug Regimens

5. A Randomized Controlled Prophylactic Study of Clofazimine To Prevent Mycobacterium Avium Complex Infection in HIV Disease

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