Search Clinical Trials
 
By Condition
 
By Location (USA)
 
By Location (Other)
 
By Sponsor
 
Resources
 
Privacy Policy
 
About Us
Disclaimer
The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia Clinical research trials and The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia. The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia clinical trial. Human subjects often get the best healthcare available for their The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.

Home > "T" Clinical Trials Conditions > The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia

The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia



The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia

For Condition: Myocardial Ischemia
Status: Completed
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: Coronary artery disease (CAD) remains the leading cause of death in the elderly. Silent myocardial ischemia (SI) is a manifestation of CAD in which there is a transient alteration in myocardial perfusion, function, and/or electrical activity not accompanied by chest pain. Mental and emotional stress, in particular hostility and anger are potent inducers of SI, Individuals with SI are at a 3-5 fold higher risk for the development of angina, myocardial infarction and death than subjects without SI.
Details: The hypothesis of this study is that older individuals with occult cad, mental stress/ emotional arousal (anger) increases sympathetic nervous system activity resulting in vasoconstriction thereby eliciting transient episodes of SI. Therefore an aerobic exercise intervention that reduces the response to anger/hostility and improves vascular compliance will decrease the ischemic burden in SI patients. The specific objectives are: To determine if non-smoking older individuals with exercise-induced SI have increased vasoreactivity (blood pressure, heart rate) responses to the laboratory presentation of mental stressors, decreased vascular compliance and brachial artery endothelial reactivity compared to matched non-ischemic controls; 2) To perform a randomized clinical trial that will examine the effects of 9 months of aerobic exercise training versus usual care on vasoreactivity, vascular compliance and ischemic burden on Holter monitor. Older individuals without a history of overt CAD will be recruited and evaluated for the presence of exercise-induced SI. Baseline cross-sectional comparisons of vasoreactivity and cardiovascular function will be performed between those with SI and non-ischemic controls. The individuals with SI will be enrolled in a randomized clinical trial of exercise vs usual care. Exercise treadmill testing with measurement of maximal aerobic capacity will be used to determine fitness. Vasoactivity will be quantified during a mental stress test with real time 2d echo imaging. Vascular function will be assessed using high frequency ultrasound measurements of flow-mediated brachial artery endothelial reactivity.
Eligibility:
Study Type:  Interventional, Randomized
Minimum Age/Maximum Age: 60 Years/
Genders: Both
Protocol Entry Criteria: Older individuals without a history of overt CAD.
Total Enrollment: 

Location and Contact Information:

VA Maryland Health Care System
Baltimore,  Maryland,  21201
United States
 


Additional Information:
Study ID Numbers:  AGCG-003-96F; 
Study Start Date: April 1997
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018252

Other Myocardial Ischemia Studies:
1. Montreal Heart Attack Readjustment Trial (M-HART)

2. Cardiovascular Disease Mortality in The NAS-NRC Twin Registry

3. Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

4. Stem Cell Study for Patients with Heart Disease

5. Women's Angiographic Vitamin and Estrogen Trial (WAVE)

Related Studies:

Other Myocardial Ischemia Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials

The Effect of Exercise Training on Mental Stress-Induced Silent Ischemia
Modify your Search

  Other Myocardial Ischemia Clinical Trials
  Other Maryland Clinical Trials
  Other Baltimore Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103