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Home > "T" Clinical Trials Conditions > The Biology of HIV Transmission  The Biology of HIV Transmission
The Biology of HIV Transmission
For Condition: HIV Infections
Status: Recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: The purpose of this study is to look at the amount of HIV in the blood, genital fluid, and saliva of the partners of patients with early HIV infection. This study will also look at the strength of the immune systems of patients with early HIV infection. Because HIV multiplies very quickly in the early stages of infection, patients with early HIV infection may be more likely to transmit HIV to their partners. The amount of HIV in blood, genital fluid, and saliva may determine the risk for transmission.
Details: Persons with early HIV infection may represent high transmission risk to their partners. Early infection, characterized by rapid virologic replication, insufficient immunologic control of infection, and more rapid course of disease progression, may be associated with increased infectiousness. The viral determinants of transmission may in part be explained by viral burden in blood, genital fluids, and oral cavity fluids. All three fluids may be the source for transmitted virus. Persons with suspected HIV infection are asked to identify their possible source partners. The importance of partner referral is emphasized and assisted recruitment or active tracing is offered if necessary. Source partners will not be approached uninvited. If a partner states that he/she does not want to be contacted, then he/she will not be contacted further for the purpose of this study or for any other study. All patients are offered HIV counseling and plasma testing for HIV-1 RNA and CD4+ cells. Blood specimens are collected for plasma determination, and cellular and plasma fractions are collected for CAF and neutralization antibodies. Neutralization assays are used to detect humoral immune response in patients with primary HIV infection. Genital fluids and saliva are analyzed for viral RNA. Patients are seen in the clinic on Day 1 for blood draw and return 2 weeks later for blood test results. A follow-up period of at least 4 weeks is planned. Compensation is provided to all patients.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients may be eligible for this study if they: - Are at least 18 years old. - Have sex with or share injection drugs with a person who is thought to have early HIV infection, or if they have recently become HIV-positive. - Can provide written consent. - Are available for a follow-up period of at least 4 weeks.
Total Enrollment: 20
Location and Contact Information:
Overall Study Official:
JamesKahn, Principal Investigator,
San Francisco Gen Hosp / UCSF AIDS Program *Recruiting*
San Francisco, California, 94110
United States
Recruiting Dr. Kahn 415-476-4082
UCSD *Recruiting*
San Diego, California, 92103
United States
Recruiting Joanne Santangelo 619-543-8080
Cedars Sinai Med Ctr *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Dr Darr 310-855-3896
Additional Information:
Study ID Numbers: AIEDRP AI-05-007; UCSD Project 98-0776,AEHIV 007
Study Start Date: October 1999
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001092
Other Hiv Infections Studies:
1. An Escalating Dose Tolerance Trial of BG8962 (rCD4) in Patients Who Are HIV Antibody Positive
2. A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients
3. Evaluation of the Interaction Between High Dose Sulfamethoxazole/Trimethoprim and Zidovudine
4. A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir
5. Longitudinal Study of Ocular Complications of AIDS (LSOCA)
Related Studies:
Other HIV Infections Clinical Trials
Other California Clinical Trials
Other San Francisco Clinical Trials
The Biology of HIV Transmission
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