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Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer Clinical research trials and Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer. Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer clinical trial. Test subjects typically receive the most effective healthcare possible for their Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "T" Clinical Trials Conditions > Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer  Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer
Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer
For Condition: Carcinoma, Non-Small-Cell Lung,Neoplasm Metastasis,Brain Neoplasms
Status: Recruiting
Sponsor(s): Schering-Plough ,
Synopsis: The purpose of this study is to demonstrate improvement in overall survival for the combination of whole brain radiation therapy (WBRT) plus temozolomide (TMZ) vs WBRT plus placebo. Secondary objective is to demonstrate an improvement in the time to radiological CNS progression with the addition of TMZ to WBRT.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: - Age greater than or equal to 18 - Histologically or cytologically confirmed non-small-cell lung cancer (NSCLC) - At least one brain metastasis diagnosed within 30 days of randomization - Brain metastases must not have been previously treated with WBRT or radiosurgery - No more than 2 sites of extracranial metastases - May have received prior radiation therapy to the primary tumor and/or systemic metastatic sites - Meets protocol requirements for specified laboratory values. - Written informed consent and cooperation of patient - Appropriate use of effective contraception if of childbearing potential. - Karnofsky Performance Status KPS greater than 70 - Score less than 2 on all criteria of the Comprehensive Neutrological Outcome Scale (CNOS)
Total Enrollment: 550
Location and Contact Information:
Eastern CT Hem/Onc Associates *Not yet recruiting*
Norwich, Connecticut, 06360
United States
Not yet recruiting Dennis Slater 860-886-8362
Dent Neurologic Institute *Recruiting*
Buffalo, New York,
United States
Recruiting Laszio Mechtler 716-877-5127
Memorial Sloan Kettering Cancer *Recruiting*
New York City, New York,
United States
Recruiting Lauren Abrey 646-227-2908
Southern Oncology Research *Recruiting*
Greenville, North Carolina, 27834
United States
Recruiting Jesse Lee 252-413-6628
Cleveland Clinic Foundation *Not yet recruiting*
Cleveland, Ohio, 44195
United States
Not yet recruiting John Suh 216-444-5574
Radiation Oncology Department *Recruiting*
Tucson, Arizona, 85724
United States
Recruiting Baldasarre Stea 520-626-6800
New York Presbyterian Hospital *Recruiting*
New York City, New York,
United States
Recruiting Susan Pannullo 212-746-2076
DeQuatto Community Cancer Center *Not yet recruiting*
Manchester, Connecticut, 06040
United States
Not yet recruiting Jeffrey Wasser 860-646-0670
The Queen's Medical Center *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Kaye Kawahara 808-537-7574
Central Baptist Hospital *Recruiting*
Lexington, Kentucky, 40503
United States
Recruiting Lee Hicks 859-276-0414
Carolina NeuroSurgery & Spine Associates *Recruiting*
Charlotte, North Carolina, 28207
United States
Recruiting Benjamin Ramis 704-371-6492
Dent Neurologic Institute *Recruiting*
Amherst, New York, 14226
United States
Recruiting Laszio Mechtler 716-250-2028
MD Anderson Cancer Center *Recruiting*
Orlando, Florida, 32806
United States
Recruiting Jennifer Tseng 321-841-1859
Metro-Minnesota Community Clinical Oncology Program *Not yet recruiting*
Minneapolis, Minnesota, 55426
United States
Not yet recruiting Timothy Larson 952-993-1545
University Hospitals of Cleveland *Recruiting*
Cleveland, Ohio, 44106
United States
Recruiting Afshin Dowlati 216-844-1637
Queen's Medical Hospital *Recruiting*
Honolulu, Hawaii,
United States
Recruiting Kaye Kawahara 808-537-7574
Cancer Specialists of South Texas *Recruiting*
Corpus Christi, Texas, 78411
United States
Recruiting Alice Chen 361-993-3456
Dana-Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Patrick Wen 617-632-3780
Prebyterian Hospital Center for Cancer Research *Recruiting*
Charlotte, North Carolina, 28233
United States
Recruiting Richard Reiling 704-384-8920
Thomas Jefferson University Hospital *Recruiting*
Philadelphia, Pennsylvania, 19107
United States
Recruiting Walter Curran 215-503-5641
Overlake Medical Hospital *Recruiting*
Bellevue, Washington,
United States
Recruiting John Rieke 425-688-5407
Cedars Sinai Cancer Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Ronald Natale 310-423-0721
Bethesda Memorial Hospital *Recruiting*
Boynton Beach, Florida, 33435
United States
Recruiting Roger Brito 561-374-5020
Medical Oncology Associations of Augusta *Recruiting*
Augusta, Georgia, 30901
United States
Recruiting Shlaer Stephen 706-722-4245
Kellogg Cancer Care Center/Evanston Hospital *Not yet recruiting*
Evanston, Illinois, 60201
United States
Not yet recruiting Nina Paleologos 847-570-2025
Odyssey Research *Recruiting*
Bismark, North Dakota, 58501
United States
Recruiting Thomas Wos 701-250-7355
Odyssey Research *Recruiting*
Bismark, North Dakota,
United States
Recruiting M Thomas 701-250-7355
Baptist Regional Hospital Cancer Center *Recruiting*
Knoxville, Tennessee, 37920
United States
Recruiting Tracy Dobbs 865-549-4107
James Brown Cancer Center *Recruiting*
Louisville, Kentucky, 40202
United States
Recruiting Donald Miller 502-562-4585
Cancer Specialists of South Texas *Recruiting*
Corpus Christi, Texas,
United States
Recruiting Alice Chen 361-993-3456
Overlake Hospital Medical Center *Recruiting*
Bellevue, Washington, 98004
United States
Recruiting John Rieke 425-688-5407
St. Luke's Mountain State Tumor *Recruiting*
Boise, Idaho, 83712
United States
Recruiting Theodore Walters 208-381-3132
Mayo Clinic *Recruiting*
Jacksonville, Florida, 32224
United States
Recruiting Kurt Jaeckle 904-953-7645
Hematology Oncology of Indiana *Recruiting*
Indianapolis, Indiana, 46260
United States
Recruiting Ruemu Birhiray 317-415-6631
University of Pittsburg Cancer Institute *Not yet recruiting*
Pittsburgh, Pennsylvania, 15232
United States
Not yet recruiting Chandra Belani 412-648-6619
Christus St. Francis Cabrini Medical Center *Not yet recruiting*
Alexandria, Louisiana, 71301
United States
Not yet recruiting Paul Zhang 318-448-6917
Sharp Memorial Hospital *Recruiting*
San Diego, California, 92123
United States
Recruiting David Bodkin 858-939-5061
H. Lee Moffitt Cancer Center & Research Institute *Recruiting*
Tampa, Florida, 33612
United States
Recruiting Susan Snodgrass 813-972-8332
Emory University - Winship Cancer Center *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Michael Fanucchi 404-778-5959
Greenville CCOP Cancer Center *Recruiting*
Greenville, South Carolina, 29615
United States
Recruiting Jeffrey Giguere 864-241-6251
Additional Information:
Study ID Numbers: P03247;
Study Start Date: December 2003
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00076856
Other Carcinoma, Non-Small-Cell Lung Studies:
1. For Prevention of Diarrhea in Patients Diagnosed with Metastatic Colorectal Cancer Treated with Chemotherapy
2. A Phase I Study of Infusional Chemotherapy with the P-Glycoprotein Antagonist PSC 833
3. A Phase I Study of OncoLAR® (Registered Trademark) (NSC 685403) with/without Tamoxifen in Patients with Osteosarcoma
4. Continuation Study of CpG 7909 in Patients with Stable Disease or Who Have Responded to Therapy for their Malignancies
5. Feasibility Study of Interleukin 1-Alpha with Ifosfamide, CBDCA, and Etoposide with Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma
Related Studies:
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Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer
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