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Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter Clinical research trials and Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter. Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter clinical trial. Subjects typically recieve the finest healthcare available for their Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
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Home > "T" Clinical Trials Conditions > Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
For Condition: Infection
Status: Recruiting
Sponsor(s): United Kingdom Children's Cancer Study Group ,
Synopsis: RATIONALE: Giving the antibioticteicoplanin by infusion and allowing bacteria to be exposed to the antibiotic for a longer period of time may be effective in preventing or controlling septicemia. PURPOSE: Randomized clinical trial to compare two different methods of giving teicoplanin in treating septicemia in patients who are receiving chemotherapy through a central venous catheter.
Details: OBJECTIVES: - Compare the response and cure rate of coagulase-negative staphylococcal septicemia in patients receiving chemotherapy through a central venous catheter treated with 2 different schedules of teicoplanin. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center and number of central venous catheter lumens (1 vs 2). Patients are randomized to one of two treatment arms. - Arm I: Patients receive teicoplanin IV bolus every 12 hours for 3 doses and then once daily for 5 doses (total of 7 days). - Arm II: Patients receive teicoplanin IV over 2 hours and/or by antibiotic lock every 12 hours for 3 doses and then once daily for 5 doses (total of 7 days). PROJECTED ACCRUAL: Approximately 490-1,360 patients will be accrued for this study within 2.2-6.2 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Suspected septicemia caused by coagulase-negative staphylococci - Single or double lumen (no triple lumen) central venous catheter (CVC) (including subcutaneous ports) that can be flushed and aspirated - Expected to remain in situ for at least 8 weeks - No coagulase-negative septicemia associated with existing CVC within the past 12 weeks - Receiving chemotherapy for neoplastic condition, aplastic anemia, Fanconi's anemia, Langerhans' cell histiocytosis, or myelodysplasia PATIENT CHARACTERISTICS: Age: - 2 months and over Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Creatinine clearance at least 60 mL/min PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - See Disease Characteristics Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
BarryPizer, Study Chair, Royal Liverpool Children's Hospital, Alder Hey
Addenbrooke's NHS Trust *Recruiting*
Cambridge, England, CB2 2QQ
United Kingdom
Recruiting Denise Williams 44-1223-216-878
Birmingham Children's Hospital *Recruiting*
Birmingham, England, B4 6NH
United Kingdom
Recruiting Bruce Morland 44-121-333-8233
Bristol Royal Hospital for Children *Recruiting*
Bristol, England, BS2 8BJ
United Kingdom
Recruiting Annabel Foot 44-117-921-5411
Royal Liverpool Children's Hospital, Alder Hey *Recruiting*
Liverpool, England, L12 2AP
United Kingdom
Recruiting Heather McDowell 44-151-228-4811
Southampton General Hospital *Recruiting*
Southampton, England, SO16 6YD
United Kingdom
Recruiting Janice Kohler 170-379-6942
Queen's Medical Centre *Recruiting*
Nottingham, England, NG7 2UH
United Kingdom
Recruiting David Walker 44-115-924-9924
Royal Marsden Hospital - Sutton *Recruiting*
Sutton, England, SM2 5PT
United Kingdom
Recruiting Kathy Pritchard-Jones 44-20-8661-3496
Royal Hospital for Sick Children *Recruiting*
Edinburgh, Scotland,
United Kingdom
Recruiting Hamish Wallace 0131-536-0426
Meyerstein Institute of Oncology at Middlesex Hospital *Recruiting*
London, England, WIT 3AA
United Kingdom
Recruiting Maria Michelagnoli 44-20-7380-9950
Great Ormond Street Hospital for Children NHS Trust *Recruiting*
London, England, WC1N 3JH
United Kingdom
Recruiting Penelope Brock 44-20-829-8832
Royal Hospital for Sick Children *Recruiting*
Glasgow, Scotland, G3 8SJ
United Kingdom
Recruiting E.M. Simpson 44-141-201-0000
Children's Hospital - Sheffield *Recruiting*
Sheffield, England, S10 2TH
United Kingdom
Recruiting Mary Gerrard 00-44-0114-271-7229
Leicester Royal Infirmary *Recruiting*
Leicester, England, LE1 5WW
United Kingdom
Recruiting Rosemary Shannon 44-116-254-1414
Royal Belfast Hospital for Sick Children *Recruiting*
Belfast, Northern Ireland, BT12 6BE
United Kingdom
Recruiting Anthony Mccarthy 44-289-063-3631
Our Lady's Hospital for Sick Children *Recruiting*
Crumlin, , 12
Ireland
Recruiting Fin Breatnach 353-1-409-6659
St. James's University Hospital *Recruiting*
Leeds, England, LS9 7TF
United Kingdom
Recruiting Adam Glaser 44-113-206-4986
Aberdeen Royal Infirmary *Recruiting*
Aberdeen, Scotland, AB25 2ZN
United Kingdom
Recruiting D.J. King 44-1224-681-818
Oxford Radcliffe Hospital *Recruiting*
Oxford, England, 0X3 9DU
United Kingdom
Recruiting Kate Wheeler 44-186-522-1066
Newcastle Upon Tyne Hospitals NHS Trust *Recruiting*
Newcastle upon Tyne, England, NE7 7DN
United Kingdom
Recruiting Andrew J. Pearson 44-191-232-5131 ext. 24101
Saint Bartholomew's Hospital *Recruiting*
London, England, EC1A 7BE
United Kingdom
Recruiting Judith Kingston 44-20-7943-1339
Manchester Children's Hospitals (NHS Trust) *Recruiting*
Manchester, England, M27 1HA
United Kingdom
Recruiting Bernadette Brennan 44-161-727-2222
Additional Information:
Study ID Numbers: CDR0000068944; EU-20124,UKCCSG-SC-1999-01
Study Start Date:
Record last reviewed: February 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00024453
Other Infection Studies:
1. Voriconazole With or Without Interferon gamma in Treating Patients With Aspergillosis or Other Fungal Infections
2. Anidulafungin in Treating Immunocompromised Children With Neutropenia
3. Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
4. Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer
5. Detection and Characterization of Host Defense Defects
Related Studies:
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Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
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