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SU5416 in Patients with AIDS-Related Kaposi's Sarcoma



SU5416 in Patients with AIDS-Related Kaposi's Sarcoma

For Condition: HIV Infections,Sarcoma, Kaposi
Status: Completed
Sponsor(s): SUGEN ,
Synopsis: The purpose of this study is to test the effectiveness of SU5416 in patients with AIDS-related KaposiÂ’s sarcoma (KS) where chemotherapy has failed.
Details: Patients are given SU5416 via twice-weekly intravenous infusions. Any patient who has not experienced unacceptable toxicity and who is deemed to be responding to the study drug (no evidence of disease progression) is permitted to continue receiving SU5416 in 4-week treatment cycles (up to a maximum of 1 year therapy) until that patient experiences either unacceptable toxicity, tumor progression, or a complete response, as defined in the protocol.
Eligibility:
Study Type:  Interventional, Treatment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients may be eligible for this study if they: - Are at least 18 years old. - Have KS. - Have taken paclitaxel, DaunoXome, or Doxil for KS and have either not gotten better or could not tolerate treatment. - Have 1 of the following symptoms for KS: 5 lesions (sores), generalized KS-related edema (swelling) without sores, or KS-related edema of the arms and legs. - Agree to use an effective method of birth control during the study. Exclusion Criteria Patients will not be eligible for this study if they: - Are pregnant or breast-feeding. - Are allergic to Cremophor.
Total Enrollment: 29

Location and Contact Information:

Alison L. Hannah
San Francisco,  California,  94080
United States
 


Additional Information:
Study ID Numbers:  310A;  SU5416.024,AMC #022
Study Start Date: 
Record last reviewed: December 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005932

Other Sarcoma, Kaposi Studies:
1. Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma

2. A Study of Ro 24-7429 in Patients with HIV-Related Kaposi's Sarcoma

3. A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma

4. A Phase I Trial of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (rHuGM-CSF), Recombinant Alpha Interferon and Azidothymidine (AZT) in AIDS-Associated Kaposi's Sarcoma

5. A Safety/Efficacy Study of SGN-30 (Antibody) in Patients with Refractory or Recurrent CD30+ Hematologic Malignancies

Related Studies:

Other Sarcoma, Kaposi Clinical Trials
Other California Clinical Trials
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SU5416 in Patients with AIDS-Related Kaposi's Sarcoma
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