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Study of Topical Calcitriol in Children With Psoriasis



Study of Topical Calcitriol in Children With Psoriasis

For Condition: Psoriasis
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Boston University School of Medicine
Synopsis: OBJECTIVES: I. Determine the therapeutic efficacy and safety of topical calcitriol in children with psoriasis.
Details: PROTOCOL OUTLINE: Patients apply topical calcitriol in petrolatum on a psoriatic lesion daily. Patients also apply petrolatum without calcitriol to another psoriatic lesion daily. Patients have both lesions photographed prior to therapy, monthly during therapy, and at the completion of therapy. Lesions are assessed weekly for 1 month and then every 2 weeks while on study. Blood samples are collected every 1 to 2 months and urine samples are collected every 2 weeks while on study.
Eligibility:
Study Type:  Interventional,�Treatment
Minimum Age/Maximum Age: 4 Years/18 Years
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnosis of psoriasis At least 2 lesions with area at least 30-50 cm2 --Prior/Concurrent Therapy-- No other concurrent therapy for psoriasis No concurrent calcium supplements greater than 1,000 mg/day No concurrent prednisone or other drugs affecting serum or urine calcium levels --Patient Characteristics-- Renal: No high blood or urinary calcium levels Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception
Total Enrollment: 20

Location and Contact Information:

Overall Study Official:
MichaelHolick,  Study Chair,  Boston University School of Medicine


Additional Information:
Study ID Numbers:  199/15372;  BUSM-90-106
Study Start Date: July 2000
Record last reviewed: September 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006275

Other Psoriasis Studies:
1. Scalp Psoriasis Treatment with a Fiber Optic Comb

2. Characterizing Serum Protein Patterns in Selected Skin Diseases

3. A Pilot Study of Topical Antiflammin-2 for Psoriasis

4. Assessment of Digital Imaging as a Tool for Diagnosing Psoriasis, Hand Rashes and Unusual Moles

5. Etanercept (Enbrel®) in Psoriasis - Pediatrics

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