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Study of the Neurobiology of Tourette Syndrome and Related Disorders



Study of the Neurobiology of Tourette Syndrome and Related Disorders

For Condition: Tourette Syndrome,Obsessive Compulsive Disorder
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Yale University
Synopsis: OBJECTIVES: I. Investigate the pathobiology of Tourette syndrome and related disorders by measuring various compounds of interest in cerebrospinal fluid, plasma, and urine of patients with Tourette syndrome, obsessive compulsive disorder, and/or chronic tics. II. Determine the pattern of familial aggregation of Tourette syndrome and obsessive compulsive disorder by systematic assessment of all first-degree family members of patients selected for cerebrospinal fluid studies. III. Establish the neurochemical and neuropeptide profile associated with the range of expression of the putative Tourette gene expression in adult and adolescent patients.
Details: PROTOCOL OUTLINE: All patients are screened with a complete physical and neurologic exam, and a semi-structured interview. Patients then receive a comprehensive assessment of systemic disease. Patients and first-degree family members also participate in a genetic study. Any patient who experiences an unusual exacerbation of symptoms or significant side effects is removed from the study.
Eligibility:
Study Type:  Observational, Screening
Minimum Age/Maximum Age: 12 Years/45 Years
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnostic and Statistical Manual of Mental Disorders IV lifetime diagnosis of 1 or more of the following: - Tourette syndrome (TS) - Obsessive compulsive disorder - Chronic tics Severely affected adolescents with a score of 3 or greater on the TS-Clinical Global Impression Scale eligible --Prior/Concurrent Therapy-- At least 1 month since any medication --Patient Characteristics-- Other: - In good physical health - No alcohol or substance abuse - No Intelligence Quotient below 80 - Negative pregnancy test required of fertile women
Total Enrollment: 200

Location and Contact Information:

Overall Study Official:
JamesLeckman,  Study Chair,  Yale University

Yale University School of Medicine
New Haven,  Connecticut,  06520-8035
United States
 


Additional Information:
Study ID Numbers:  199/11866;  YALESM-4601
Study Start Date: December 1988
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004325

Other Tourette Syndrome Studies:
1. Magnetic Resonance Spectroscopy to Evaluate Tourette's Syndrome

2. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder

3. Central Mechanisms in Speech Motor Control Studied with H215O PET

4. Evaluation and Follow-up of Individuals with Obsessive-Compulsive Disorder and Related Conditions

5. Phase II Pilot Controlled Study of Short vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome

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