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Home > "S" Clinical Trials Conditions > Study of the Effects of Temperature on Metabolism in Human Muscle  Study of the Effects of Temperature on Metabolism in Human Muscle
Study of the Effects of Temperature on Metabolism in Human Muscle
For Condition: Healthy
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: This study will examine the role of temperature in changing energy metabolism in human muscle. In order to do this, researchers will use magnetic resonance imaging (MRI) to provide information about how parts of muscle operate during exercise. Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). In this study, MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise. In addition, the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle.
Details: This study will examine the role of temperature in modulating aspects of energy metabolism in human skeletal muscle. Tests will be conducted at rest and during concentric dorsiflexion exercise of the Tibialis anterior (TA) muscle using an existing custom-designed dynamometer in conjunction with mild local heating and cooling. Magnetic resonance spectroscopy (MRS), performed in a 4-tesla whole-body NMR system, will be used to non-invasively measure muscle temperature and energy-state. Specifically these tests will assess the extent to which temperature changes occur during aerobic exercise and how small temperature changes affect mitochondrial function in-vivo.
Eligibility:
Study Type: Interventional, Treatment, Safety
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Ages 18 to 50. Male and female subjects. Capable of giving informed consent. Healthy normal volunteers. No cardiac pacemaker of implantable defibrillator. No aneurysm clip. No neural stimulator (e.g. TENS-unit). No ear implant of any type. No metal in the eye (e.g. from machining). No implanted device (e.g. insulin pump, drug infusion device). No metallic foreign body, shrapnel, or bullet.
Total Enrollment: 17
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 980166; 98-H-0166
Study Start Date: September 28, 1998
Record last reviewed: August 24, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001753
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Study of the Effects of Temperature on Metabolism in Human Muscle
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