|
Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer Clinical research trials and Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer. Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer clinical trial. Participants typically obtain the most effective healthcare available for their Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "S" Clinical Trials Conditions > Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer  Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer
Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer
For Condition: Brain Neoplasms,Carcinoma, Non-Small-Cell Lung,Metastases, Neoplasm
Status: Completed
Sponsor(s): Schering-Plough ,
Synopsis: Brain metastases from solid tumors are diagnosed in more than 300,000 patients annually. Nonsmall cell lung cancer accounts for the majority of CNS mets. Treatment with whole brain radiation and steroids will improve neurologic symptoms in about 50% of patients although survival is short. This study will test the safety and efficacy of temozolomide in combination with radiation therapy in the treatment of patients with brain mets form nonsmall cell lung cancer.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Histologic confirmation of non-small-cell lung cancer - Stable systemic disease - Maximum of one prior chemotherapy regimen for metastatic systemic disease - Radiotherapy for local control or palliative bony lesions is allowed - Karnofsky of greater than or equal to 70% - Adequate hematologic, renal and liver function Exclusion Criteria: - Patients eligible for surgery of the brain - Any previous chemotherapy for the brain metastasis - Chemotherapy within 4 weeks or previous temozolomide - Prior radiotherapy to the brain - Radiation therapy to greater than 50% of the bone marrow - Insufficient recovery from previous therapies - Active nonmalignant systemic disease - Inability to take oral medication - Pregnant or nursing women - Non use of adequate contraceptive techniques, negative urine pregnancy test is required - Known AIDS related illness
Total Enrollment: 60
Location and Contact Information:
Christie Hospital
Manchester, , M204BX
United Kingdom
University of Colorado Cancer Center
Denver, Colorado, 80220-3706
United States
Anschutz Cancer Pavilion
Aurora, Colorado,
United States
Additional Information:
Study ID Numbers: P02143;
Study Start Date: June 2001
Record last reviewed: July 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00034697
Other Metastases, Neoplasm Studies:
1. Study of DN101 and Taxotere in patients with advanced non-small cell lung cancer
2. Safety/Efficacy study of immunoconjugate with docetaxel in non-small cell lung carcinoma
3. Safety and efficacy of ABR-217620 in patients with advanced non-small cell lung cancer.
4. This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.
5. Study of 111In-DAC as an Medical Imaging Agent for Lung Cancer and Brain Cancer Consistent with Metastatic Lung Cancer
Related Studies:
Other Metastases, Neoplasm Clinical Trials
Other Colorado Clinical Trials
Other Denver Clinical Trials
Study of Temozolomide in the Treatment of Brain Metastasis from Non-small-cell Lung Cancer
|
|
|
|
|
|
|
|
