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Study of Pituitary Size and Function in Familial Dwarfism of Sindh



Study of Pituitary Size and Function in Familial Dwarfism of Sindh

For Condition: Growth Hormone Deficiency
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Northwestern University
Synopsis: OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan. II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.
Details: PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated. All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: 10 Years/60 Years
Genders: Both
Protocol Entry Criteria: - Familial Dwarfism of Sindh - Severe short stature but proportionate without dysmorphic features - Normal body size and weight at birth - Bone age is severely delayed - Puberty is somewhat delayed (age 15-16) - Fertility present in at least 3 dwarfs
Total Enrollment: 4

Location and Contact Information:

Overall Study Official:
GerhardBaumann,  Study Chair,  Northwestern University


Additional Information:
Study ID Numbers:
  199/11940;  NU-571
Study Start Date: September 1995
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004365

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