|
Study of Norepinephrine Levels and Sympathetic Nervous System Activity Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, trips or professional assistance with a real medical doctor. We aren't docs. Always confer with your doctor about Study of Norepinephrine Levels and Sympathetic Nervous System Activity conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Study of Norepinephrine Levels and Sympathetic Nervous System Activity Clinical research trials and Study of Norepinephrine Levels and Sympathetic Nervous System Activity health trials happen in many of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the effectualness of new does drugs. The intention of the studies / projects is to figure out particular human healthcare questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to detect cures for all forms of circumstances, like Study of Norepinephrine Levels and Sympathetic Nervous System Activity. Study of Norepinephrine Levels and Sympathetic Nervous System Activity Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment options before they are available to the general public. Most times the subjects get treatment for free of charge, and occasionally they are paid for their time. Occasionally there is a cost for a Study of Norepinephrine Levels and Sympathetic Nervous System Activity clinical trial. Subjects frequently get the best healthcare possible for their Study of Norepinephrine Levels and Sympathetic Nervous System Activity condition. Hazards are a reality, however, and could include more or frequent mD visits, health risks (possibly life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with exacting guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "S" Clinical Trials Conditions > Study of Norepinephrine Levels and Sympathetic Nervous System Activity  Study of Norepinephrine Levels and Sympathetic Nervous System Activity
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
For Condition: Autonomic Nervous System Disease,Healthy,Hypertension
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the sympathetic nervous system. The sympathetic nervous system is involved with regulating blood pressure and pulse rate. Researchers believe the level norepinephrine in the blood can be used to measure activity of the sympathetic nervous system. This study is designed to answer important questions about rates of release of norepinephrine into the blood stream, removal of released norepinephrine, and the sympathetic nervous system response to stress. Researchers will attempt to measure levels of norepinephrine and activity of the sympathetic nervous system in patients with high blood pressure, normal patients with family histories of high blood pressure, patients taking drugs that can effect levels of norepinephrine, and patients with diseases or conditions directly affecting the sympathetic nervous system.
Details: In order to examine sympathetic nervous system function in neurocardiological disorders and catecholaminergic effects of dietary manipulations or neuropsychiatric drugs, the protocol calls for evaluations of the kinetics of 3H-norepinephrine or 3H-epinephrine in patients with hypertension, dysautonomias, or disorders thought to involve abnormal catecholaminergic function, and in normotensive normal volunteers. Apparent spillover and clearance rates are estimated based on the norepinephrine or epinephrine concentration during the infusion and their steady-state specific activities, under resting conditions and in response to physiological or pharmacological manipulations thought to affect sympathetic outflows.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Must be greater than or equal to 18 years of age. Must not be pregnant or lactating.
Total Enrollment: 50
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 920259; 92-N-0259
Study Start Date: September 4, 1992
Record last reviewed: September 11, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001329
Other Autonomic Nervous System Disease Studies:
1. Electromyography to Diagnose Neuromuscular Disorders
2. Cause of Pigment Dispersion Syndrome
3. Study of Brain Changes Shaped by Experience
4. Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
5. PET Scans in Normal Volunteers and Patients with Fabry Disease
Related Studies:
Other Autonomic Nervous System Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
|
|
|
|
|
|
|
|
