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Home > "S" Clinical Trials Conditions > Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation  Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
For Condition: long-term effects secondary to cancer therapy in children,Pulmonary Complications
Status: No longer recruiting
Sponsor(s): Fred Hutchinson Cancer Research Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Assessing the long-term effects of bone marrow transplantation on lung function in patients may improve the ability to plan treatment. PURPOSE: Study to determine the long-term effects on lung function in children who have undergone bone marrow transplantation.
Details: OBJECTIVES: - Determine the delayed effects of bone marrow transplantation preparative regimens on pulmonary function in children surviving at least 5 years after transplantation for hematologic malignancy. - Determine the relationship between pulmonary function and growth rates in these patients. - Determine the effect of growth hormone treatment on pulmonary function in these patients. - Determine the relationship between pulmonary function and age at time of transplantation in these patients. - Determine the incidence and severity of restrictive pulmonary disease, and whether these factors vary with increasing time after transplantation in these patients. OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement. Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated. PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /17 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Patients who have undergone bone marrow transplantation for hematologic malignancy at least 5 years ago - Disease-free survivors at least 6 years of age AND - Under 18 years of age at time of transplantation - Received prior allogeneic, unrelated donor, syngeneic, or autologous bone marrow transplantation - Able to perform pulmonary function tests PATIENT CHARACTERISTICS: Age: - See Disease Characteristics Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - See Disease Characteristics Chemotherapy: - Not specified Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - Not specified Other: - Any prior preparative regimen allowed
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JeanSanders, Study Chair, Fred Hutchinson Cancer Research Center
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024
United States
Additional Information:
Study ID Numbers: CDR0000065808; FHCRC-1097.00,NCI-G00-1911
Study Start Date:
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00009711
Other Pulmonary Complications Studies:
1. Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy
2. Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis
3. Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
4. Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
5. Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer
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Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
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