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Study of Low Bone Mass in Premenopausal or Perimenopausal Women



Study of Low Bone Mass in Premenopausal or Perimenopausal Women

For Condition: Osteoporosis
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Columbia University
Synopsis: OBJECTIVES: I. Determine the possible causes of bone loss in premenopausal or perimenopausal women.
Details: PROTOCOL OUTLINE: Patients undergo physical examination and complete history with emphasis on risk factors for osteoporosis and screening for occult secondary causes of osteoporosis through blood serum and 24 hour urine collection. Patients with more than 6 months since prior bone mineral density measurements or who did not receive measurements at participating center, undergo dual energy x-ray absorptiometry over 30 minutes for bone mineral density measurements.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: 16 Years/54 Years
Genders: Female
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Low bone mass (T score less than -2.0) with no secondary cause on routine exam - Premenopausal OR - Perimenopausal --Prior/Concurrent Therapy-- - Chemotherapy: No prior or concurrent chemotherapeutic agents - Endocrine therapy: No prior or concurrent glucocorticoids or suppressive doses of thyroid hormone - Other: No prior or concurrent anticonvulsants --Patient Characteristics-- - Hematopoietic: No multiple myeloma - Other: No hyperparathyroidism No thyrotoxicosis No anorexia nervosa No Paget's disease of bone No rheumatoid arthritis No Cushing's syndrome No malabsorption syndrome No type I diabetes mellitus
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
ElizabethShane,  Study Chair,  Columbia University

Columbia University College of Physicians and Surgeons
New York City,  New York,  10032
United States
 


Additional Information:
Study ID Numbers:
  NCRR-M01RR00645-2738;  CPMC-IRB-8414,CPMC-GCRC-2738
Study Start Date: February 1998
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005101

Other Osteoporosis Studies:
1. Patient- and Physician-Based Osteoporosis Education

2. Nitroglycerin Ointment for Preventing Bone Loss in Postmenopausal Women

3. Raloxifene With or Without Exercise Compared With Exercise Alone in Women Who Have Been Previously Treated for Breast Cancer

4. Effect of Androgen Suppression on Bone Loss in Patients With or Without Bone Metastases Secondary to Prostate Cancer

5. A School-Based Osteoporosis Prevention Program for Adolescent Girls

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