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Home > "S" Clinical Trials Conditions > Study of Inherited Changes of Receptors Located on Blood Vessels  Study of Inherited Changes of Receptors Located on Blood Vessels
Study of Inherited Changes of Receptors Located on Blood Vessels
For Condition: Cardiovascular Disease
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: The renin angiotensin system is a complex process involving hormones and enzymes that regulate blood volume and blood pressure. The hormone angiotensin II is responsible for making blood vessels narrow or constrict. Angiotensin II is found in the blood and can attach to special sites called receptors on blood vessel walls. These receptors are programmed to accept angiotensin II and cause a constriction of the blood vessel. This function is found in the genetic information of each individual person. Occasionally patients have changes in their genes related to angiotensin II receptors. These changes may result in the receptors acting differently to angiotensin II, which may affect the function of blood vessels. This study is designed to improve researchers understanding of the physiological effects on blood vessels associated with mutations of the genes responsible for angiotensin II receptor function.
Details: Polymorphisms in the genes encoding for various elements of the renin angiotensin system have been associated with cardiovascular disease. We have isolated novel alleles in the angiotensin II type I receptor gene. We propose this exploratory investigation to study the physiological effect of these mutations on vascular function in patients and family members who carry these rare alleles.
Eligibility:
Study Type: Interventional, Treatment, Safety
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients aged 21 or older with chronic orthostatic intolerance will be included. There will be no exclusion from participation in the study on the basis of ethnicity/race. Patients will be recruited in the Cardiology Branch outpatient clinic, Dr. David Goldstein (Chief Neurocardiology Section, NINDS, NIH), or from outside physicians. Children will be excluded from the study because of inability in obtaining informed consent. Cognitively impaired individuals, prisoners, or other institutionalized persons will not be able to participate.
Total Enrollment: 200
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 980029; 98-H-0029
Study Start Date: November 7, 1997
Record last reviewed: April 24, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001741
Other Cardiovascular Disease Studies:
1. Metabolic Differences of Overweight Children and Children of Overweight Parents
2. Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
3. Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
4. Angiomax in Patients with HIT/HITTS Type II Undergoing CPB
5. Gender, Obesity, C-Reactive Protein, and Oxidative Stress
Related Studies:
Other Cardiovascular Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Study of Inherited Changes of Receptors Located on Blood Vessels
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