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Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis



Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

For Condition: IGA Glomerulonephritis
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),Ohio State University
Synopsis: OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N). II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.
Details: PROTOCOL OUTLINE: Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: - IgA glomerulonephritis
Total Enrollment: 105

Location and Contact Information:

Overall Study Official:
LeeHebert,  Study Chair,  Ohio State University

Ohio State University
Columbus,  Ohio, 
United States
 


Additional Information:
Study ID Numbers:
  199/11791;  OSU-94H0338
Study Start Date: January 1998
Record last reviewed: April 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004305

Other Iga Glomerulonephritis Studies:
1. Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

2. Pilot Study of Enalapril and Renal Function in Patients With IgA Nephropathy

3. Alternate Day Prednisone or Daily Fish Oil Supplements in Patients with Immunoglobulin A Nephropathy

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Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

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