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Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment using a real mD. We aren't mDs. Always confer with your physician on Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer Clinical research trials and Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer healthcare trials happen in a lot of of localities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / undertakings is to answer particular human medical questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, such as Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer. Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer Clinical Trials and other clinical trials allow volunteers to get healthcare treatment alternatives before they are available to the general public. Most times the participants receive treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer clinical trial. Human subjects often receive the most effective healthcare possible for their Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer condition. Risks are a reality, nonetheless, and may include more or frequent dr. calls, healthcare hazards (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "S" Clinical Trials Conditions > Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer
Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer
For Condition: Pancreatic Cancer
Status: Recruiting
Sponsor(s): M.D. Anderson Cancer Center ,
Synopsis: The goal of this clinical research study is to find the highest safe dose of the drug Bevacizumab that can be given in combination with chemoradiation for the treatment of pancreatic cancer. The effect that this combination treatment has on the tumor will also be studied.
Details: This study administers 50.4 Gy of radiation for unresectable pancreatic cancer with concurrent capecitabine and an experimental drug, Bevacizumab. The drug is an antiangiogenic agent (kills tumor blood vessels) and has been shown in preclinical models to enhance the antitumor effect of radiation and chemotherapy.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety Study
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Inclusion: - Cytology or histologic proof of adenocarcinoma of the pancreatic head, body or tail prior to treatment. - Patients with nonmetastatic, unresectable, disease are eligible. - Patients with regional nodal disease are eligible. - Karnofsky performance status >/=70. - No upper age restriction. - Absolute granulocyte count >1,500 cells/mm3 and platelet count at least 100,000 cells/mm3. - Serum bilirubin less than 5mg/dl prior to the start of therapy with adequate biliary decompression. - Adequate bilateral renal function. - Serum creatinine <1.5 mg/dl. - Adequate liver function; Alanine aminotransferase (ALT)/aspartate aminotransferase (AST)=5 times upper limit of normal. - Sexually active men must practice contraception during study. - Patients must sign study-specific consent form. Exclusion: - History or evidence upon physical examination of CNS disease. - Active infection requiring parenteral antibiotics on Day 0. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, or anticipation of need for major surgical procedure during the course of the study. - Current or recent use of full-dose oral or parenteral anticoagulants or thrombolytic agent. - Chronic, daily treatment with aspirin or nonsteroidal anti-inflammatory medications. - Pregnancy or lactation. - Proteinuria at baseline or impairment of renal function. - Serious, nonhealing wound, ulcer, or bone fracture. - Evidence of bleeding diathesis or coagulopathy - Clinically significant cardiovascular disease, congestive heart failure, serous cardiac arrhythmia requiring medication, or significant peripheral vascular disease within 1 year prior to Day 0. - History of aneurysms, strokes, transient ischemic attacks, and arteriovenous malformations. - Serous concomitant medical or psychiatric disorders. - Cohort receiving Capecitabine
Total Enrollment: 48
Location and Contact Information:
University of Texas MDAnderson Cancer Center *Recruiting*
Houston, Texas, 77030
United States
Recruiting Christopher Crane 713-563-2340
Additional Information:
Study ID Numbers: ID02-146;
Study Start Date: September 2002
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00047710
Other Pancreatic Cancer Studies:
1. Photodynamic Therapy in Treating Patients With Cancer of the Bile Duct, Gallbladder, or Pancreas
2. Irinotecan and Capecitabine in Treating Patients With Solid Tumors
3. A study with Gemzar and LY293111 in patients with pancreatic cancer.
4. Biological Therapy in Treating Patients With Metastatic Cancer
5. Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum
Related Studies:
Other Pancreatic Cancer Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials
Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients with Locally Advanced Pancreatic Cancer
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