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Study of Brain Control of Movement



Study of Brain Control of Movement

For Condition: Movement Disorder,Healthy
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease. Normal healthy volunteers between the ages of 18 and 65 years may be eligible to participate. In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's scalp or skin. Brief electrical currents are passed through the coil, creating magnetic pulses that stimulate the brain. During the stimulation, participants will be asked to tense certain muscles slightly or perform other simple actions. The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle. In most cases, the study will last less than 3 hours.
Details: The purpose of this study is to investigate the influence of voluntary inhibition of movement, using either negative motor imagery or Go/NoGo reaction task, on cortical inhibitory mechanisms. Intracortical inhibition (ICI) and silent period (SP) are two major cortical inhibitory mechanisms demonstrated by transcranial magnetic stimulation (TMS). Alterations in these inhibitory mechanisms have been extensively studied in various situations, but the influence of voluntary inhibition has not been elucidated yet. In normal volunteers, therefore, we plan to determine if voluntary inhibition of movement influences these cortical inhibitory mechanisms. The primary outcome measures would be any changes in motor evoked potential (MEP) size and intracortical inhibition (ICI) parameters.
Eligibility:
Study Type:  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Volunteers who are greater than or equal to 18 years old. Subjects must not have any medico-surgical illness. Subjects must not have neurological illness. Subjects must not have psychiatric illness. Subjects must not be taking any medication with potential influence on nervous system function. Subjects must not have a pacemaker. Subjects must not have an implanted medical pump. Subjects must not have a metal plate or a metal object in the skull or eye. Subjects must not have a history of seizure disorder.
Total Enrollment: 30

Location and Contact Information:

National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda,  Maryland,  20892
United States
 


Additional Information:
Study ID Numbers:  010200;  01-N-0200
Study Start Date: June 21, 2001
Record last reviewed: June 12, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00017979

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