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Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) Clinical research trials and Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide). Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) clinical trial. Test subjects typically receive the most expert healthcare available for their Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide) condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "S" Clinical Trials Conditions > Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)  Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
For Condition: Healthy,Hypercapnia
Status: Recruiting
Sponsor(s): Warren G Magnuson Clinical Center (CC) ,
Synopsis: This study will evaluate magnetic resonance imaging (MRI ) methods for measuring changes in the brain's blood flow during hypercapnia (a condition of excess carbon dioxide in the blood). MRI is a diagnostic tool that uses a large magnet and radio waves to produce images of the body without X-rays. Healthy normal volunteers in this study may have as many as six MRI scans over a 2-year period. For this procedure, the person lies on a stretcher placed in a strong magnetic field produced by the MRI machine. During the scan, the person's blood carbon dioxide (CO2 ) levels will be increased either by: 1) breathing air mixtures containing up to 5% CO2; or 2) receiving an intravenous (I.V.) injection of a drug called acetazolamide. Persons who breathe CO2 will have their heart rate, blood pressure and oxygen levels monitored throughout the procedure. Those receiving acetazolamide will have the drug injected intravenously (I.V.) into an arm vein. If the volunteer experiences any unpleasant side effects from the CO2 or acetazolamide, the study will be stopped. The information gained from this study will be used to develop better ways to study brain function, possibly leading to better diagnostic and treatment methods.
Details: Advances in MR perfusion imaging have provided clinical researchers with the opportunity to quantitate regional increases in cerebral blood flow. The purpose of this study is to acquire the technical experience required to perform MR perfusion imaging studies of the hypercapnic cerebral blood flow response. Cerebral blood flow will be increased by inhalation of carbogen (an air mixture containing 5% CO2) or IV injection of the carbonic anhydrase inhibitor acetazolamide. The technical experience obtained in this study will be used to design a study of the pharmacological and physiological mechanisms underlying cerebral blood flow increases during hypercapnia.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Any normal volunteer above the age of 18 years old who is capable of giving informed consent. EXCLUSION CRITERIA: Subjects will be excluded if they have contraindications to MR scanning, such as the following: aneurism clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, chochlear implant, ocular foreign body (e.g., metal shavings), or insulin pump. Also, subjects will be excluded if they have panic disorder or migrane (because of possible complications with CO2 inhilation), or if they have cirrhosis, are on high dose aspirin therapy, or have an allergy to acetazolamide injection). Subjects will be excluded if they have allergies to sulfonamide drugs or if they have a chronic respiratory illness.
Total Enrollment: 30
Location and Contact Information:
Warren G. Magnuson Clinical Center (CC) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 990164; 99-CC-0164
Study Start Date: September 8, 1999
Record last reviewed: September 8, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001845
Other Hypercapnia Studies:
1. Role of Prostaglandins in the Regulation of Brain Blood Flow
2. Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
Related Studies:
Other Hypercapnia Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
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