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Home > "S" Clinical Trials Conditions > Study of Brain Activity during Speech Production and Speech Perception  Study of Brain Activity during Speech Production and Speech Perception
Study of Brain Activity during Speech Production and Speech Perception
For Condition: Developmental Articulation Disorder,Stuttering
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: The purpose of this study is to gain a better understanding of the brain's activity and organization in the development of speech disorders. It will compare brain activity in people with normal speech development with those who stutter or who have a phonological disorder (a deficit in how the brain processes speech sounds). Stuttering and phonological disorders emerge during the critical period of speech development between 2.5 and 12 years of age. During this period, the brain is much more adaptable for speech development than it is after puberty. This study will examine how the brain organization for speech production and perception develops normally during the critical period and how the normal pattern is altered when stuttering and phonological disorders become chronic problems, persisting throughout life. Volunteer adults and children with and without speech disorders may participate in this study. Eligibility screening will include a brief neurological and physical examination and tests to determine normal speech or a speech disorder. The speech testing will be videotaped. The subject will speak aloud, describe pictures, recall words or numbers, imitate speech sounds and words, and perform some listening tests. Study participants will undergo magnetic resonance imaging (MRI) to study brain activity. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. During the MRI scan, the subject will perform simple tasks, such as listening to speech or other sounds and saying nonsense words. The procedure should take less than 60 minutes, and usually takes from 20 to 40 minutes.
Details: This is a study of two developmental speech production disorders, which emerge during the critical period of speech development between 2.5 and 12 years of age. During this critical period there is considerably greater brain plasticity for speech functioning which disappears following puberty. Our purpose is to determine how normal brain organization for speech production and perception develops during the critical period and how this normal pattern is altered when stuttering and phonological disorders become chronic problems, persisting throughout the life span. Functional MRI is a non-invasive methodology suitable for research in these disorders in children. New methodologies using fMRI provide the first opportunity for the study of speech production both in normally developing children as well as children and adults with stuttering and/or phonological disorders. Our hypothesis is that, with development, the brain organization for speech production becomes less distributed involving fewer brain regions, and that phonological processing mechanisms become lateralized to the left hemisphere during the critical period of speech development. This research will address whether the brain regions involved in speech are more diffuse and less selective in persons who develop chronic stuttering and phonological disorders, leading to a less efficient dynamic system for speech production.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Subjects who have been diagnosed exclusively with stuttering or a phonological processing disorder, as well as their affected and unaffected family members, will be recruited. Because brain organization for speech and language may differ in bilingual persons, only native-American English speakers, with only one language spoken in the home, will be included. All subjects will be right-handed on the Edinburgh handedness questionnaire. Only persons who have given their written consent for participation in the study will be included in our research. EXCLUSION CRITERIA: A subject will be excluded if he/she has a contraindication to MR scanning such as the following: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or autodefibrillator; cochlear implant; ocular implant or foreign body (e.g. metal shavings or splinters); insulin pump; shrapnel; bullet or shot wound; artificial heart valve; tattooed makeup; prostheses of ferromagnetic material; surgical metal clips in the brain, eye or on blood vessels; implanted drug infusion device; intraventricular shunts, transdermal medication patches, wire sutures, bone/joint pins, screws, nails, plates, and body piercings. Other exclusion criteria are pregnancy (as determined by pregnancy testing at NIH's Clinical Center on the day of scanning); speech reception thresholds greater than 25 dB; left-handedness on the Edinburgh handedness questionnaire; non-native American English speech; developmental exposure to a language other than English in the home; language and/or cognitive functioning lower than 1 standard deviation below the age-adjusted mean value on screening tests.
Total Enrollment: 165
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 000095; 00-N-0095
Study Start Date: March 14, 2000
Record last reviewed: January 29, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004991
Other Developmental Articulation Disorder Studies:
1. Characteristics of Idiopathic Familial Speech Disorders
2. Study of Brain Activity during Speech Production and Speech Perception
Related Studies:
Other Developmental Articulation Disorder Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Study of Brain Activity during Speech Production and Speech Perception
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