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Home > "S" Clinical Trials Conditions > Study of antioxidants and oxidants in malnourished children  Study of antioxidants and oxidants in malnourished children
Study of antioxidants and oxidants in malnourished children
For Condition: Kwashiorkor,Marasmus,Protein-Energy Malnutrition
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: It is believed that the organs of severely malnourished children malfunction because harmful compounds called oxidants injure the tissues in these organs. In a healthy person oxidants are made harmless because another compound called glutathione neutralizes them. Glutathione is made from three amino acids that we get from the protein we eat in our food. We found that malnourished children were not making enough glutathione because they lacked one of these amino acids called cysteine. In this study we determine why malnourished children do not have sufficient cysteine, and we will feed malnourished children a whey-based diet which is rich in cysteine during their treatment to determine whether they will make more glutathione. This in turn may make their organs recover faster. These findings will let us know whether malnourished children can recover faster if they are given more cysteine during the early phase of treatment.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 6 Months/18 Months
Genders: Both
Protocol Entry Criteria: - Infants and toddlers, 6-18 months of age - Suffering from severe protein-energy malnutrition, kwashiorkor and marasmic-kwashiorkor
Total Enrollment: 84
Location and Contact Information:
Overall Study Official:
FarookJahoor, Principal Investigator, Baylor College of Medicine
Tropical Metabolism Research Unit, University of the West Indies *Recruiting*
Kingston, Saint Andrew, Kingston-7
Jamaica
Recruiting Terrence Forrester 876-702-4687
Additional Information:
Study ID Numbers: GLUTH;
Study Start Date: June 2003
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00069134
Other Marasmus Studies:
1. Study of antioxidants and oxidants in malnourished children
Related Studies:
Other Marasmus Clinical Trials
Other Saint Andrew Clinical Trials
Other Kingston Clinical Trials
Study of antioxidants and oxidants in malnourished children
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