|
Stress Hormones and Human Cocaine Use - 7 Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or treatment with a real dr.. We aren't doctors. Always consult your mD on Stress Hormones and Human Cocaine Use - 7 conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Stress Hormones and Human Cocaine Use - 7 Clinical research trials and Stress Hormones and Human Cocaine Use - 7 medical trials occur in many of places across the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectiveness of new does drugs. The role of the studies / undertakings is to figure out certain human healthcare questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to locate treatments for all forms of circumstances, including Stress Hormones and Human Cocaine Use - 7. Stress Hormones and Human Cocaine Use - 7 Clinical Trials and other clinical trials permit volunteers to get medical treatment options before they are available to the masses. Most times the human subjects acquire treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Stress Hormones and Human Cocaine Use - 7 clinical trial. Participants oftentimes recieve the finest healthcare available for their Stress Hormones and Human Cocaine Use - 7 condition. Dangers are a reality, nonetheless, and might include extra or frequent physician calls, health hazards (potentially life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "S" Clinical Trials Conditions > Stress Hormones and Human Cocaine Use - 7  Stress Hormones and Human Cocaine Use - 7
Stress Hormones and Human Cocaine Use - 7
For Condition: Cocaine-Related Disorders
Status: Completed
Sponsor(s): National Institute on Drug Abuse (NIDA) , University of Minnesota
Synopsis: To determine the HPA axis and adrenergic system activation in response to cocaine administration.
Details: The goal of this study was to investigate the role of sympathetic-adrenal medullary (SAM) and hy0pothalamo-pituitary-adrenal (HPA) systems in mediating the addictive effects of cocaine. A toal of 6 male subjects were enrolled for this 5 day inpatient study. Subjects were assigned to either cocaine (32mg /70kg iv) or placebo (saline iv) treatment during the first experimental sessions and were crossed over to the alternative treatment during the second experimental session. Endpoints that were followed during the experimental sessions included neuroendocrine (serum epinephrine, norepinephrine and cortisol levels), physological (heart rate/blood pressure, EKG) and subjective measures (Beck Depression Inventory, Craving Questionnaire). We hypothesized that cocaine administration would lead to increased blood levels of norpinephrine, epinephrine and cortisol in cocaine dependent subjects.
Eligibility:
Study Type: Interventional, Treatment, Double-Blind, Placebo Control, Crossover Assignment
Minimum Age/Maximum Age: 20 Years/45 Years
Genders: Male
Protocol Entry Criteria: Inclusion Criteria: Males between the ages of 20-45. History of smoked or intravenous cocaine use on the average of at least once a week over a 6 month period. Current history of good health and normal EKG. Exclusion Criteria: History of suicide attempt, bipolar disorder, schizophrenia, or generalized anxiety disorder. Current problem with major depressive disorder. Current use of alcohol or other drugs on a daily basis. History of major medical illnesses. Currently on parole, probation or a legal history of violence. Treatment for chemical dependency within the past 6 months. History of sensitivity to tricyclic compounds or other prescription drugs. Use of any psychotropic drugs including MAOIs in the past 6 months.
Total Enrollment: 0
Location and Contact Information:
Overall Study Official:
DorothyHatsukami, Principal Investigator, University of Minnesota
University of Minnesota
Minneapolis, Minnesota, 55455
United States
Additional Information:
Study ID Numbers: NIDA-09259-7; P50-09259-7
Study Start Date: May 1997
Record last reviewed: January 1998
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000290
Other Cocaine-Related Disorders Studies:
1. Pharmacotherapy and Intensive Treatment of Drug Abuse - 1
2. CREST-I: Resperine, Gabapentin, or Lamotrigine vs. Placebo - 7
3. Carbamazepine Treatment of Cocaine Dependence - 1
4. Cocaine-Methylphendidate Interaction Study - 4
5. Mazindol for Cocaine Abuse - 2
Related Studies:
Other Cocaine-Related Disorders Clinical Trials
Other Minnesota Clinical Trials
Other Minneapolis Clinical Trials
Stress Hormones and Human Cocaine Use - 7
|
|
|
|
|
|
|
|
