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Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis Clinical research trials and Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis. Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis clinical trial. Participants oftentimes recieve the most expert healthcare available for their Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "S" Clinical Trials Conditions > Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis  Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis
Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis
For Condition: Pulmonary Fibrosis,Rheumatoid Arthritis
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Researchers hope to improve their understanding of the disease process involved in PF and RA by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or autopsy from patients with these conditions. The purpose of this study is to collect specimens from rheumatoid arthritis patients with and without pulmonary fibrosis as well as patients with pulmonary fibrosis without associated diseases or cause (idiopathic pulmonary fibrosis).
Details: The etiology of pulmonary fibrosis in individuals with rheumatoid arthritis is unknown. Analysis of blood and specimens procured by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from patients with this disorder will contribute to our understanding of the pathogenetic mechanisms of pulmonary fibrosis in rheumatoid arthritis. The purpose of this protocol is to obtain blood and specimens by bronchoscopy, lung biopsy, lung transplantation, or post-mortem examination from rheumatoid arthritis patients with and without pulmonary fibrosis, individuals with idiopathic pulmonary fibrosis, and healthy research volunteers.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Non-smokers (never smoked or not smoked within the previous 2 years) who are 18 years of age or older with any of the following: RA with PF (biopsy-proven), or RA-only, or Idiopathic PF-only (biopsy-proven), or Healthy research volunteers by history and indicated tests (individuals without history of chronic cardiopulmonary disorder, collagen vascular disease, or bleeding disorder) matched for age (within 5 years) and gender. EXCLUSION CRITERIA: Individuals with any of the following: Forced expiratory volume in one second (FEV(1)) less than 1L. Inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal, beryllium). Chronic cardiopulmonary disorders other than pulmonary fibrosis. Other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease). Non-rheumatoid arthritis. Viral infections associated with PF (i.e., hepatitis B, hepatitis C, human immunodeficiency virus). Uncorrectable bleeding diathesis. Pregnancy or lactation.
Total Enrollment: 9999
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 990068; 99-H-0068
Study Start Date: March 21, 1999
Record last reviewed: March 18, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001884
Other Rheumatoid Arthritis Studies:
1. Patient Education in Rheumatoid Arthritis and Osteoarthritis
2. Meditation-based stress reduction in rheumatoid arthritis
3. Long term safety and tolerability of an investigational drug in patients with rheumatoid arthritis
4. Efficacy & Safety of an Investigational Drug + Methotrexate Compared to Methotrexate Alone in Patients with Rheumatoid Arthritis
5. Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis
Related Studies:
Other Rheumatoid Arthritis Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Specimen Collection for Individuals with Lung Disease Associated with Rheumatoid Arthritis
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