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Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical research trials and Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome. Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome clinical trial. Subjects often receive the most expert healthcare possible for their Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "S" Clinical Trials Conditions > Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
For Condition: Meningitis, Cryptococcal,HIV Infections
Status: Completed
Sponsor(s): Liposome ,
Synopsis: To evaluate the safety, tolerance and efficacy of three different dosage regimens of Amphotericin B Lipid Complex (ABLC) compared to Fungizone (Amphotericin B) in patients with AIDS and cryptococcal meningitis.
Details:
Eligibility:
Study Type: Interventional, Treatment, Dose Comparison, Safety Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Intravenous pentamidine for treatment of Pneumocystis carinii pneumonia (PCP) but not for prophylaxis. Patients must have the following: - Meet the CDC criteria for diagnosis of AIDS. - Confirmed episode of acute cryptococcal meningitis. - Informed consent of the patient or guardian prior to entry. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Clinical evidence of acute or chronic meningitis due to an agent other than Cryptococcus neoformans. - History of hypersensitivity/anaphylactoid reaction attributed to amphotericin B. - Any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. Concurrent Medication: Excluded: - Corticosteroids. - Salicylates or other drugs known to interfere with prostaglandin synthesis except as specified in protocol. - Zidovudine. - Investigational agents. - Interferon. - Interleukin-2 (IL-2). - Steroids. - Isoprinosine. - Intrathecal Amphotericin B. - Intravenous Pentamidine PCP prophylaxis (only treatment). Patients with the following are excluded: - Clinical evidence of acute or chronic meningitis due to an agent other than Cryptococcus neoformans. - History of hypersensitivity/anaphylactoid reaction attributed to amphotericin B. - Inability to obtain appropriate follow-up visits. - Any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. Prior Medication: Excluded within 4 weeks of study entry: - Amphotericin B. - Excluded within 2 weeks of study entry: - Any other experimental drug.
Total Enrollment:
Location and Contact Information:
Audie L Murphy Veterans Administration Hosp
San Antonio, Texas, 78284
United States
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, 60612
United States
East Orange Veterans Administration Med Ctr
East Orange, New Jersey, 07018
United States
Saint Luke's - Roosevelt Hosp Ctr
New York City, New York, 10025
United States
Univ TX Galveston Med Branch
Galveston, Texas, 77550
United States
Mount Sinai Med Ctr / Jack Martin Fund Clinic
New York City, New York, 10029
United States
Dr Thomas Patterson
New Haven, Connecticut, 06510
United States
Univ of Utah School of Medicine
Salt Lake City, Utah, 84132
United States
Buckley Braffman Stern Med Associates
Philadelphia, Pennsylvania, 19107
United States
Natl Naval Med Ctr
Bethesda, Maryland, 20889
United States
Dr Dorothy Friedberg
New York City, New York, 10016
United States
Harbor - UCLA Med Ctr
Torrance, California, 90502
United States
New York Univ Med Ctr
New York City, New York, 10016
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Walter Reed Army Med Ctr
Washington D.C., District of Columbia, 203075001
United States
Saint Michael's Med Ctr
Newark, New Jersey, 07102
United States
Cornell Univ Med College
New York City, New York, 10021
United States
Beth Israel Med Ctr / Peter Krueger Clinic
New York City, New York, 10003
United States
Univ Hosp
Boston, Massachusetts, 02118
United States
Additional Information:
Study ID Numbers: 051A;
Study Start Date:
Record last reviewed: November 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002019
Other Meningitis, Cryptococcal Studies:
1. A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.
2. The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients with HIV and Cryptococcal Meningitis
3. Dexamethasone in Cryptococcal Meningitis
4. A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success with Amphotericin B
5. A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients with AIDS
Related Studies:
Other Meningitis, Cryptococcal Clinical Trials
Other New York Clinical Trials
Other New York City Clinical Trials
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
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