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Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele Clinical research trials and Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele. Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele clinical trial. Subjects frequently obtain the most expert healthcare possible for their Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
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Home > "R" Clinical Trials Conditions > Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele  Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele
Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele
For Condition: Male Infertility,Non-obstructive azoospermia,Varicocele,Hypospermatogenesis
Status: Recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this study is to identify markers that predict the outcome of variocele correction. This would offer considerable health cost savings. Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
Details:
Eligibility:
Study Type: Observational, Screening, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 21 Years/55 Years
Genders: Male
Protocol Entry Criteria: - Healthy male with varicocele (grades 2 [palpable] or 3 [visible, palpable]) and no other diagnosed cause for infertility - Non-smoker - Actively desiring children but never having initiated a pregnancy - Female partner having no unresolved fertility issues
Total Enrollment: 400
Location and Contact Information:
Overall Study Official:
SusanBenoff, Principal Investigator, North Shore University Hospital
North Shore University Hospital *Recruiting*
Manhasset, New York, 11030
United States
Recruiting Susan Benoff 516-562-1121
University of Medicine and Dentistry of NJ, Robert Wood Johnson Medical School at Camden *Recruiting*
Camden, New Jersey, 08103
United States
Recruiting Joel Marmar 609-963-3577
Additional Information:
Study ID Numbers: 10496-CP-001;
Study Start Date: May 2000
Record last reviewed: August 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00044369
Other Non-Obstructive Azoospermia Studies:
1. Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele
Related Studies:
Other Non-obstructive azoospermia Clinical Trials
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Role of the toxic metal cadmium in the mechanism producing infertility with a varicocele
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