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Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment



Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment

For Condition: HIV Infections
Status: Recruiting
Sponsor(s): Gathe, Joseph, M.D. ,
Synopsis: The purpose of this study is to determine if treatment with an anti-HIV drug containing ritonavir and Agenerase is safe and can lower the level of HIV in the blood in patients who have failed an anti-HIV drug treatment containing nelfinavir.
Details: HIV-infected patients will be treated with a ritonavir-enhanced Agenerase regimen.
Eligibility:
Study Type:
  Interventional, Treatment, Safety Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients may be eligible for this study if they: - Are 18 years of age or older. - Are HIV-positive. - Have a viral load (level of HIV in the body) of more than 1,000 copies/ml. - Have had more than 12 weeks of prior anti-HIV drug treatment. - Have failed a previous anti-HIV treatment containing nelfinavir as the only protease inhibitor. - Are responsive to Agenerase. - Are able to follow study requirements. Exclusion Criteria Patients will not be eligible for this study if they: - Are intolerant to ritonavir (an anti-HIV drug). - Have or have had problems with absorption. - Have liver disease or damage. - Have pancreatic disease or damage. - Have taken any protease inhibitor other than nelfinavir. - Are receiving investigational drugs or devices from another study. - Are pregnant or breast-feeding. - Currently use triazolam, astemizole, ergot medications, cisapride, midazolam, bepridil, rifampin, terfenadine, or pimozide. - Have a bleeding disorder. - Have previously been treated with Agenerase. - Are receiving nonnucleosides.
Total Enrollment: 

Location and Contact Information:

Gathe, Joseph, M.D. *Recruiting*
Houston,  Texas,  77004
United States
Recruiting Marketer  Washington 713-526-9821


Additional Information:
Study ID Numbers:
  313A;  APV-430
Study Start Date: 
Record last reviewed: October 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006591

Other Hiv Infections Studies:
1. A Study of Patients Who Develop HIV Infection After Enrolling in HIV Vaccine Trials or HIV Vaccine Preparedness Trials

2. A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP

3. Effect of Anti-HIV Therapy (HAART) on HIV Levels in the Lungs and on Lung Cell Inflammation in HIV-Infected Patients

4. A Phase I/II Safety and Immunogenicity Trial of UBI Microparticulate Monovalent (HIV-1 MN) Branched Peptide Vaccine in HIV-1 Seronegative Human Subjects

5. Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

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Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment

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