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Regulation of Sterol Homeostasis



Regulation of Sterol Homeostasis

For Condition: Hypertriglyceridemia
Status: No longer recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol. This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.
Details:
Eligibility:
Study Type:
  Observational, Natural History, Cross-Sectional, Defined Population, Prospective Study
Minimum Age/Maximum Age: 18 Years/75 Years
Genders: Both
Protocol Entry Criteria: Hypertriglyceridemia and normal controls with normal lipids
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
LorenZech,  , 

VA Medical Center
Minneapolis,  Minnesota,  55417
United States
 


Additional Information:
Study ID Numbers:
  GAST-026-95F; 
Study Start Date: April 1996
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018720

Other Hypertriglyceridemia Studies:
1. Genetic Determinants:Low HDL, High Triglycerides, Obesity

2. Re-evaluating Triglycerides in Coronary Heart Disease

3. The Effect of Fish Oil Plus Fenofibrate on Triglyceride Levels in People Taking Highly Active Antiretroviral Therapy (HAART)

4. Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

5. Regulation of Sterol Homeostasis

Related Studies:

Other Hypertriglyceridemia Clinical Trials
Other Minnesota Clinical Trials
Other Minneapolis Clinical Trials

Regulation of Sterol Homeostasis

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