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Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope



Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope

For Condition: Syncope
Status: Recruiting
Sponsor(s): Mount Sinai Medical Center ,
Synopsis: OBJECTIVES: Determine the efficacy of midodrine, a selective alpha 1 adrenergic agonist, in preventing neurally mediated syncope.
Details: PROTOCOL OUTLINE: This is a randomized, double-blind, crossover, placebo-controlled study. On day one, patients receive either midodrine or placebo. On day three, patients receive the opposite drug.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind
Minimum Age/Maximum Age: 16 Years/
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnosis of neurally mediated syncope (vasovagal fainting) Sudden fall in blood pressure AND Slowing of the heart AND Temporary loss of consciousness AND Hemodynamic response to head up tilt --Prior/Concurrent Therapy-- No other concurrent adrenergic agonist or antiagonist --Patient Characteristics-- Fertile patients must use effective birth control
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
HoracioKaufmann,  Study Chair,  Mount Sinai Medical Center

Mount Sinai School of Medicine *Recruiting*
New York City,  New York,  10029
United States
Recruiting Horacio  Kaufmann 212-241-7315


Additional Information:
Study ID Numbers:
  199/14181;  MTS-GCO-97-160NE,ROBERTS-MTS-GCO-97-160NE
Study Start Date: March 1999
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004479

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2. Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope

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