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Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer



Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer

For Condition: stage 1 non-small cell lung cancer,stage 2 non-small cell lung cancer
Status: No longer recruiting
Sponsor(s): Fox Chase Cancer Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining radiofrequency ablation with surgery in treating patients who have stage I or stage II non-small cell lung cancer.
Details: OBJECTIVES: - Determine the acute effects of intraoperative radiofrequency tumor ablation (RFA) in patients with resectable non-small cell lung cancer. - Determine the treatment-related toxicity in patients treated with this therapy. - Determine the dimensions of the RFA lesion produced by the ablation procedure in these patients. OUTLINE: Patients undergo intraoperative radiofrequency tumor ablation over 10-15 minutes for each tumor immediately followed by tumor resection. PROJECTED ACCRUAL: A maximum of 20 patients will be accrued for this study.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Diagnosis of malignant non-small cell lung cancer (NSCLC) - Intraoperative needle biopsy confirmation allowed - Resectable disease (stage I or II) - All tissue to be treated by radiofrequency tumor ablation must be completely contained within boundaries of planned lung resection - Medically fit to undergo lung resection PATIENT CHARACTERISTICS: Age: - Over 18 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Other: - Not pregnant or nursing PRIOR CONCURRENT THERAPY: Biologic therapy: - No prior or concurrent biologic therapy Chemotherapy: - No prior or concurrent chemotherapy Endocrine therapy: - No prior or concurrent endocrine therapy Radiotherapy: - No prior or concurrent radiotherapy Surgery: - See Disease Characteristics Other: - No other prior therapy for NSCLC
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
WalterScott,  Study Chair,  Fox Chase Cancer Center

Fox Chase Cancer Center
Philadelphia,  Pennsylvania,  19111
United States
 


Additional Information:
Study ID Numbers:
  CDR0000069389;  FCCC-02007,NCI-G02-2079
Study Start Date: 
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00039507

Other Stage 1 Non-Small Cell Lung Cancer Studies:
1. Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer

2. Standard Therapy Given With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer

3. PET Scan in Patients With Lung and Esophageal Cancers That May Be Removed by Surgery

4. Radiation Therapy Using 3-Dimensional Treatment Planning in Patients With Non-small Cell Lung Cancer

5. Bevacizumab, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Cell Lung Cancer

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Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer

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