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Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases Clinical research trials and Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases. Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases clinical trial. Subjects frequently obtain the most expert healthcare possible for their Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
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Home > "R" Clinical Trials Conditions > Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases  Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases
Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases
For Condition: brain metastases
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) , Jonsson Comprehensive Cancer Center
Synopsis: RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells in a single high dose. Combining radiation therapy with surgery may be a more effective treatment for brain metastases. PURPOSE: Clinical trial to study the effectiveness of radiation therapy with or without surgery in treating patients who have brain metastases.
Details: OBJECTIVES: I. Develop prognostic factors for patients with brain metastases treated by focal treatment without concurrent whole brain irradiation. II. Determine whether focal treatment without whole brain radiotherapy produces good long-term outcome in patients with four or less cerebral metastases. III. Assess survival, physical and cognitive functioning, and quality of life of patients treated on this protocol. PROTOCOL OUTLINE: Quality of life is assessed using the FACT-BR scale, physical function is assessed using the FIM scale, and cognition is assessed using two brief pencil and paper tests. Patients receive focal therapy for cerebral metastases by any combination of (1) surgery plus fractionated stereotactic radiotherapy to surgical bed, or (2) single fraction stereotactic radiotherapy by linear accelerator with or without a radiation sensitizer. Patients are followed at 2 and 10 weeks, then every 3 months for 18 months, then every 6 months for 3 years, then annually. Quality of life is assessed at each followup visit. Patients suffering intracerebral relapse are offered further focal therapy if they have no more than 3 metastases, no more than 6 lesions over consecutive scans, and continue to have life expectancy of at least 3 months and Karnofsky performance status of 60-100%. Otherwise, relapsed patients are offered whole brain radiotherapy or supportive treatment with steroids, and may also receive stereotactic boost to the new lesions. Patients who have received prior whole brain irradiation will be offered entry into other protocols if eligible or supportive treatment with steroids. Patients are followed as above. PROJECTED ACCRUAL: At least 60 patients will be enrolled in this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Biopsy, CT scan, or MRI proven cerebral metastases with known current or previous systemic malignancy OR Biopsy proven cerebral metastases other than from small cell lung cancer or lymphoma - No more than four cerebral metastases on MRI scan and suitable for focal treatment with surgery and/or stereotactic radiotherapy with a linear accelerator - Refused whole brain radiation therapy OR Received prior whole brain radiation therapy and ineligible for other relapse protocols --Prior/Concurrent Therapy-- Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Concurrent steroids allowed Radiotherapy: - No more than 2 weeks since prior focal radiation - See Disease Characteristics Surgery: No more than 2 weeks since prior focal surgery --Patient Characteristics-- Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: At least 3 months Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JudithFord, Study Chair, Jonsson Comprehensive Cancer Center
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Additional Information:
Study ID Numbers: CDR0000066275; UCLA-HSPC-9710074,NCI-G98-1417,UCLA-HSPC-971007401
Study Start Date: December 1998
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003324
Other Brain Metastases Studies:
1. Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain
2. Melatonin and Radiation Therapy in Treating Patients With Brain Metastases
3. Temozolomide and Vinorelbine in Treating Patients With Recurrent Brain Metastases
4. Temozolomide in Treating Patients With Brain Metastases
5. Radiation Therapy Plus Gadolinium Texaphyrin in Treating Patients With Brain Metastases
Related Studies:
Other brain metastases Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
Radiation Therapy With or Without Surgery in Treating Patients Who Have Brain Metastases
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