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Radiation Therapy Following Surgery to Remove Brain Metastases Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Radiation Therapy Following Surgery to Remove Brain Metastases conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Radiation Therapy Following Surgery to Remove Brain Metastases Clinical research trials and Radiation Therapy Following Surgery to Remove Brain Metastases healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Radiation Therapy Following Surgery to Remove Brain Metastases. Radiation Therapy Following Surgery to Remove Brain Metastases Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Radiation Therapy Following Surgery to Remove Brain Metastases clinical trial. Human subjects often obtain the finest healthcare possible for their Radiation Therapy Following Surgery to Remove Brain Metastases condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "R" Clinical Trials Conditions > Radiation Therapy Following Surgery to Remove Brain Metastases  Radiation Therapy Following Surgery to Remove Brain Metastases
Radiation Therapy Following Surgery to Remove Brain Metastases
For Condition: Brain Neoplasms,Metastasis
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) , Jonsson Comprehensive Cancer Center
Synopsis: RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy after surgery to remove brain metastases may decrease the amount of radiation required to treat brain metastases. PURPOSE: Pilot trial to study the effectiveness of radiation therapy following surgery to remove brain metastases.
Details: OBJECTIVES: I. Assess the safety and tolerability of focal stereotactic radiotherapy to the surgical bed following excision of cerebral metastases, as an alternative to whole brain irradiation. II. Measure the local relapse rate at the surgical site after surgery and stereotactic radiotherapy in patients with cerebral metastases. III. Measure the regional relapse rate, in the brain but away from the treated site, following treatment in these patients. PROTOCOL OUTLINE: All patients undergo surgical removal of their cerebral metastases followed by adjuvant fractionated stereotactic radiotherapy daily for 5 days. Patients are given up to 5 weeks following surgery to recover and reach the required performance status. Radiotherapy must commence within 6 weeks of surgery. Patients are followed at 2 weeks after treatment, monthly for 6 months, every 3 months for the next 18 months, every 6 months for the next year, and then annually for years 3-5. PROJECTED ACCRUAL: There will be 20-40 patients accrued into this study.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Histologically confirmed cerebral metastases post surgical resection; No greater than 3 cerebral metastases postresection - Gross resection at operation as documented in operation note and postoperative MRI - Patients must have current surgical sites that have not been previously irradiated - No other indication for whole brain irradiation (i.e., multiple untreated metastases not suitable for single fraction stereotactic radiotherapy, leptomeningeal disease) --Prior/Concurrent Therapy-- - Biologic therapy: Not specified - Chemotherapy: No concurrent chemotherapy - Endocrine therapy: Prior or concurrent required steroids allowed - Radiotherapy: No prior whole brain irradiation or focal irradiation to current sites of disease; Prior stereotactic radiotherapy of cerebral metastases allowed provided no prior irradiation of current surgical sites - Surgery: Prior surgery of cerebral metastases allowed --Patient Characteristics-- - Age: 18 and over - Performance status: Karnofsky 60-100% - Life expectancy: At least 3 months - Hematopoietic: Not specified - Hepatic: Not specified - Renal: Not specified - Pulmonary: No severe asthma requiring therapy - Other: No allergy to iodine or contrast media; Not pregnant
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JudithFord, Study Chair, Jonsson Comprehensive Cancer Center
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Additional Information:
Study ID Numbers: CDR0000066270; UCLA-HSPC-970101503,NCI-G98-1416,UCLA-HSPC-970101502
Study Start Date: March 1997
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003320
Other Metastasis Studies:
1. Phase I Study of Vioxx and Radiation Therapy for Brainstem Glioma
2. Surgery Versus Radiosurgery to Treat Metastatic Brain Tumors
3. Temozolomide for Treatment of Brain Metastases from Non-Small Cell Lung Cancer
4. Study of 111In-DAC as an Medical Imaging Agent for Lung Cancer and Brain Cancer Consistent with Metastatic Lung Cancer
5. Study of Neurologic Progression with Motexafin Gadolinium and Radiation Therapy (SMART)
Related Studies:
Other Metastasis Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
Radiation Therapy Following Surgery to Remove Brain Metastases
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