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Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma Clinical research trials and Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma. Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma clinical trial. Human subjects often get the best healthcare available for their Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.

Home > "R" Clinical Trials Conditions > Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma

Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma



Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma

For Condition: untreated childhood brain stem glioma
Status: No longer recruiting
Sponsor(s): United Kingdom Children's Cancer Study Group ,
Synopsis: RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Tamoxifen may kill tumor cells by blocking the enzymes necessary for cell growth. Combining radiation therapy with tamoxifen may be effective in treating newly diagnosed brain stem glioma. PURPOSE: Phase II trial to study the effectiveness of combining radiation therapy and tamoxifen in treating children who have newly diagnosed brain stem glioma.
Details: OBJECTIVES: - Determine whether high-dose tamoxifen with radiotherapy increases the median survival and overall survival of children with newly diagnosed brain stem gliomas. - Determine the time to neurologic or radiographic progression in patients treated with this regimen. - Determine the acute and chronic toxicity of high-dose tamoxifen in these patients. OUTLINE: This is a multicenter study. Patients undergo radiotherapy once daily 5 days a week for 6 weeks. Within 2 weeks after the initiation of radiotherapy, patients receive oral high-dose tamoxifen once daily. Tamoxifen continues in the absence of disease progression or unacceptable toxicity. PROJECTED ACCRUAL: Approximately 60 patients will be accrued for this study within 4 years.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: /19 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Newly diagnosed tumor of the brain stem (diffuse intrinsic lesion centered on the pons) - Radiological and clinical diagnostic criteria allowed (biopsy not required) - The following astrocytic tumors are allowed if histologically confirmed: - Diffuse astrocytoma (all subtypes) - Anaplastic astrocytoma - Glioblastoma - Pilocytic astrocytoma (grade I) - Less than 6 months since diagnosis - At least 1 of the following signs of brain stem tumor: - Cranial nerve deficit - Long tract signs - Ataxia - No focal lesions of the brain stem (either clearly marginated or cystic), cervicomedullary tumors, tumors predominately exophytic, or pontine tumors diagnosed as pilocytic on biopsy PATIENT CHARACTERISTICS: Age: - Under 20 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Other: - Not pregnant or nursing - No frequent vomiting or other medical condition that would preclude oral medication intake PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy for brain stem glioma Endocrine therapy: - Concurrent steroids allowed Radiotherapy: - No prior radiotherapy for brain stem glioma Surgery: - Not specified Other: - Concurrent anticonvulsants allowed
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
AntonyMichalski,  Study Chair,  Hospital for Sick Children NHS Trust

Royal Hospital for Sick Children
Edinburgh,  Scotland, 
United Kingdom
 

Hospital for Sick Children NHS Trust
London,  England,  WC1N 3JH
United Kingdom
 

Middlesex Hospital- Meyerstein Institute
London,  England,  WIT 3AA
United Kingdom
 

Aberdeen Royal Infirmary
Aberdeen,  Scotland,  AB25 2ZN
United Kingdom
 

Oxford Radcliffe Hospital
Oxford,  England,  0X3 9DU
United Kingdom
 

Southampton General Hospital
Southampton,  England,  SO16 6YD
United Kingdom
 

Royal Belfast Hospital for Sick Children
Belfast,  Northern Ireland,  BT12 6BE
United Kingdom
 

Our Lady's Hospital for Sick Children
Crumlin,  ,  12
Ireland
 

Queen's Medical Centre
Nottingham,  England,  NG7 2UH
United Kingdom
 

Saint Bartholomew's Hospital
London,  England,  EC1A 7BE
United Kingdom
 

Manchester Children's Hospitals (NHS Trust)
Manchester,  England,  M27 1HA
United Kingdom
 

Birmingham Children's Hospital
Birmingham,  England,  B4 6NH
United Kingdom
 

Newcastle Upon Tyne Hospitals NHS Trust
Newcastle upon Tyne,  England,  NE7 7DN
United Kingdom
 

Royal Liverpool Children's Hospital, Alder Hey
Liverpool,  England,  L12 2AP
United Kingdom
 

Royal Hospital for Sick Children
Glasgow,  Scotland,  G3 8SJ
United Kingdom
 

St. James's Hospital
Leeds,  England,  LS9 7TF
United Kingdom
 

Llandough Hospital
Penarth,  Wales,  CF64 2XX
United Kingdom
 

Bristol Royal Hospital for Children
Bristol,  England,  BS2 8BJ
United Kingdom
 

Royal Marsden Hospital
Sutton,  England,  SM2 5PT
United Kingdom
 

Addenbrooke's NHS Trust
Cambridge,  England,  CB2 2QQ
United Kingdom
 

Leicester Royal Infirmary
Leicester,  England,  LE1 5WW
United Kingdom
 

Children's Hospital - Sheffield
Sheffield,  England,  S10 2TH
United Kingdom
 


Additional Information:
Study ID Numbers:
  CDR0000068920;  UKCCSG-CNS-1999-06,EU-20123
Study Start Date: 
Record last reviewed: September 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00024336

Other Untreated Childhood Brain Stem Glioma Studies:
1. Tipifarnib and Radiation Therapy in Treating Young Patients With Brainstem Glioma

2. Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas

3. Irinotecan Followed by Radiation Therapy and Temozolomide in Treating Children With Newly Diagnosed Brain Tumor

4. Imatinib Mesylate With or Without Radiation Therapy in Treating Children With Newly Diagnosed or Recurrent Glioma

5. Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma

Related Studies:

Other untreated childhood brain stem glioma Clinical Trials
Other England Clinical Trials
Other Bristol Clinical Trials

Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma

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