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Quit Smoking Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Quit Smoking conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Quit Smoking Clinical research trials and Quit Smoking health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Quit Smoking. Quit Smoking Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Quit Smoking clinical trial. Participants oftentimes recieve the most expert healthcare available for their Quit Smoking condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "Q" Clinical Trials Conditions > Quit Smoking  Quit Smoking
Quit Smoking
For Condition: Smoking
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: This protocol evaluates the efficacy of combining pharmacologic treatments for smoking cessation, entailing the use of the nicotine skin patch with the nicotinic antagonist mecamylamine, with a specific behavioral therapy designed to inhibit the smoking urge.
Details: Previous studies have found that nicotine/mecamylamine treatment more than doubles the long-term abstinence rates relative to nicotine replacement alone. Recent evidence supports the hypothesis that nicotine/mecamylamine treatment prior to smoking cessation partially blocks the rewarding effects of cigarette smoking and hence promotes extinction of the smoking habit, facilitating subsequent abstinence. The behavioral approach employed is also an extinction strategy and involves having smokers switch to de-nicotinized tobacco cigarettes for two weeks prior to quitting smoking. It is hypothesized that the use of de-nicotinized cigarettes might provide more complete extinction than provided by the partial pharmacologic blockade using nicotine/mecamylamine alone. The pharmacologic treatment was expected to increase compliance with the de-nicotinized cigarette smoking regimen, because subjects' usual brands of cigarettes will be less appealing than in the absence of nicotine/mecamylamine treatment. Together the brand-switching and nicotine/mecamylamine therapies were expected to reduce cravings and other withdrawal symptoms as well as increase long-term abstinence from smoking.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: - Smokers, - Ages 18-65, wanted to quit smoking. - Must be in good health - Exclude cardiac disease, hypotensive or hypertensive, skin allergy, glaucoma, prostatic hypertrophy, pregnant women, drug or alcohol abuse, kidney disease.
Total Enrollment:
Location and Contact Information:
Overall Study Official:
EricWestman, ,
Veterans Affairs Medical Center *Recruiting*
Durham, North Carolina, 27705
United States
Recruiting Jed Rose 919-416-1515
Additional Information:
Study ID Numbers: ADRD-008-97F;
Study Start Date: January 1997
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018161
Other Smoking Studies:
1. Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers
2. Behavioral Counseling for Alcohol Dependent Smokers (nicotine patch)
3. Quit Smoking
4. Theory-based Interventions for Smoking and Obesity (Challenge) Trial
5. Implementing Smoking Cessation Guidelines: A Randomized Trial of Evidence-Based Quality Improvement
Related Studies:
Other Smoking Clinical Trials
Other North Carolina Clinical Trials
Other Durham Clinical Trials
Quit Smoking
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