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Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder



Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder

For Condition: Schizophrenia,Schizoaffective Disorder
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: The purpose of this research study is to determine whether a new drug for schizophrenia is better for the maintenance treatment than a standard drugs currently prescribed. The new medication is called quetiapine and it will be compared with a standard medication called haloperidol decanoate. The study will determine if quetiapine causes fewer problems than haloperidol with side effects such as stiffness and restlessness and whether it costs the VA more or less to treat patients with quetiapine. In addition, blood samples will be collected every three months to determine if certain chemicals in the blood can influence the outcome of the subjects' illness.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Uncontrolled, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/60 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria 1. Schizophrenia or Schizoaffective Disorder diagnosed by DSM-IV 2. Between the ages 18-60. 3. A candidate for maintenance antipsychotic therapy. This means that patients will have had at least two documented episodes of acute schizophrenic illness or at least two years of continuing psychotic symptoms. Exclusion Criteria 1. Organic brain disease. 2. Mental Retardation 3. Chronic medical illness which would make antipsychotic medication inappropriate.
Total Enrollment: 

Location and Contact Information:

VA Greater Los Angeles Healthcare System *Recruiting*
Los Angeles,  California,  90073
United States
Recruiting Kathleen  Johnston 310-268-4565


Additional Information:
Study ID Numbers:
  MHBS-042-96F; 
Study Start Date: April 1997
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018642

Other Schizophrenia Studies:
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2. Trial Evaluating the Safety and Efficacy of 2 Doses of ER OROS Paliperidone in Acute Adult Schizophrenics

3. Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia

4. Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia

5. Trial of D-Cycloserine in Schizophrenia

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Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder

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